High-throughput small molecule screening reveals Nrf2-dependent and -independent pathways of cellular stress resistance

Aging is the dominant risk factor for most chronic diseases. Development of antiaging interventions offers the promise of preventing many such illnesses simultaneously. Cellular stress resistance is an evolutionarily conserved feature of longevity. Here, we identify compounds that induced resistance...

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Detalles Bibliográficos
Autores principales: Lombard, David B., Kohler, William J., Guo, Angela H., Gendron, Christi, Han, Melissa, Ding, Weiqiao, Lyu, Yang, Ching, Tsui-Ting, Wang, Feng-Yung, Chakraborty, Tuhin S., Nikolovska-Coleska, Zaneta, Duan, Yuzhu, Girke, Thomas, Hsu, Ao-Lin, Pletcher, Scott D., Miller, Richard A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7852388/
https://www.ncbi.nlm.nih.gov/pubmed/33008901
http://dx.doi.org/10.1126/sciadv.aaz7628

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