Organoid systems to study the human female reproductive tract and pregnancy

Both the proper functioning of the female reproductive tract (FRT) and normal placental development are essential for women’s health, wellbeing, and pregnancy outcome. The study of the FRT in humans has been challenging due to limitations in the in vitro and in vivo tools available. Recent developme...

Descripción completa

Detalles Bibliográficos
Autores principales: Alzamil, Lama, Nikolakopoulou, Konstantina, Turco, Margherita Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7852529/
https://www.ncbi.nlm.nih.gov/pubmed/32494027
http://dx.doi.org/10.1038/s41418-020-0565-5
_version_ 1783645840559046656
author Alzamil, Lama
Nikolakopoulou, Konstantina
Turco, Margherita Y.
author_facet Alzamil, Lama
Nikolakopoulou, Konstantina
Turco, Margherita Y.
author_sort Alzamil, Lama
collection PubMed
description Both the proper functioning of the female reproductive tract (FRT) and normal placental development are essential for women’s health, wellbeing, and pregnancy outcome. The study of the FRT in humans has been challenging due to limitations in the in vitro and in vivo tools available. Recent developments in 3D organoid technology that model the different regions of the FRT include organoids of the ovaries, fallopian tubes, endometrium and cervix, as well as placental trophoblast. These models are opening up new avenues to investigate the normal biology and pathology of the FRT. In this review, we discuss the advances, potential, and limitations of organoid cultures of the human FRT.
format Online
Article
Text
id pubmed-7852529
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-78525292021-02-08 Organoid systems to study the human female reproductive tract and pregnancy Alzamil, Lama Nikolakopoulou, Konstantina Turco, Margherita Y. Cell Death Differ Review Article Both the proper functioning of the female reproductive tract (FRT) and normal placental development are essential for women’s health, wellbeing, and pregnancy outcome. The study of the FRT in humans has been challenging due to limitations in the in vitro and in vivo tools available. Recent developments in 3D organoid technology that model the different regions of the FRT include organoids of the ovaries, fallopian tubes, endometrium and cervix, as well as placental trophoblast. These models are opening up new avenues to investigate the normal biology and pathology of the FRT. In this review, we discuss the advances, potential, and limitations of organoid cultures of the human FRT. Nature Publishing Group UK 2020-06-03 2021-01 /pmc/articles/PMC7852529/ /pubmed/32494027 http://dx.doi.org/10.1038/s41418-020-0565-5 Text en © The Author(s), under exclusive licence to ADMC Associazione Differenziamento e Morte Cellulare 2020 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Alzamil, Lama
Nikolakopoulou, Konstantina
Turco, Margherita Y.
Organoid systems to study the human female reproductive tract and pregnancy
title Organoid systems to study the human female reproductive tract and pregnancy
title_full Organoid systems to study the human female reproductive tract and pregnancy
title_fullStr Organoid systems to study the human female reproductive tract and pregnancy
title_full_unstemmed Organoid systems to study the human female reproductive tract and pregnancy
title_short Organoid systems to study the human female reproductive tract and pregnancy
title_sort organoid systems to study the human female reproductive tract and pregnancy
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7852529/
https://www.ncbi.nlm.nih.gov/pubmed/32494027
http://dx.doi.org/10.1038/s41418-020-0565-5
work_keys_str_mv AT alzamillama organoidsystemstostudythehumanfemalereproductivetractandpregnancy
AT nikolakopouloukonstantina organoidsystemstostudythehumanfemalereproductivetractandpregnancy
AT turcomargheritay organoidsystemstostudythehumanfemalereproductivetractandpregnancy

Ejemplares similares