Increased expression of glutamine transporter SNAT2/SLC38A2 promotes glutamine dependence and oxidative stress resistance, and is associated with worse prognosis in triple-negative breast cancer

BACKGROUND: Glutamine (Gln) is an abundant nutrient used by cancer cells. Breast cancers cells and particularly triple-receptor negative breast cancer (TNBC) are reported to be dependent on Gln to produce the energy required for survival and proliferation. Despite intense research on the role of the...

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Detalles Bibliográficos
Autores principales: Morotti, Matteo, Zois, Christos E., El-Ansari, Rokaya, Craze, Madeleine L., Rakha, Emad A., Fan, Shih-Jung, Valli, Alessandro, Haider, Syed, Goberdhan, Deborah C. I., Green, Andrew R., Harris, Adrian L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7852531/
https://www.ncbi.nlm.nih.gov/pubmed/33028955
http://dx.doi.org/10.1038/s41416-020-01113-y

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