Neutrophils in liver diseases: pathogenesis and therapeutic targets

Previously, it was assumed that peripheral neutrophils are a homogeneous population that displays antimicrobial functions. However, recent data have revealed that neutrophils are heterogeneous and are additionally involved in tissue damage and immune regulation. The phenotypic and functional plastic...

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Autores principales: Liu, Kai, Wang, Fu-Sheng, Xu, Ruonan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7852892/
https://www.ncbi.nlm.nih.gov/pubmed/33159158
http://dx.doi.org/10.1038/s41423-020-00560-0
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author Liu, Kai
Wang, Fu-Sheng
Xu, Ruonan
author_facet Liu, Kai
Wang, Fu-Sheng
Xu, Ruonan
author_sort Liu, Kai
collection PubMed
description Previously, it was assumed that peripheral neutrophils are a homogeneous population that displays antimicrobial functions. However, recent data have revealed that neutrophils are heterogeneous and are additionally involved in tissue damage and immune regulation. The phenotypic and functional plasticity of neutrophils has been identified in patients with cancer, inflammatory disorders, infections, and other diseases. Currently, neutrophils, with their autocrine, paracrine, and immune modulation functions, have been shown to be involved in liver diseases, including viral hepatitis, nonalcoholic steatohepatitis, alcoholic liver disease, liver fibrosis, cirrhosis, liver failure, and liver cancer. Accordingly, this review summarizes the role of neutrophils in liver diseases.
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spelling pubmed-78528922021-02-08 Neutrophils in liver diseases: pathogenesis and therapeutic targets Liu, Kai Wang, Fu-Sheng Xu, Ruonan Cell Mol Immunol Review Article Previously, it was assumed that peripheral neutrophils are a homogeneous population that displays antimicrobial functions. However, recent data have revealed that neutrophils are heterogeneous and are additionally involved in tissue damage and immune regulation. The phenotypic and functional plasticity of neutrophils has been identified in patients with cancer, inflammatory disorders, infections, and other diseases. Currently, neutrophils, with their autocrine, paracrine, and immune modulation functions, have been shown to be involved in liver diseases, including viral hepatitis, nonalcoholic steatohepatitis, alcoholic liver disease, liver fibrosis, cirrhosis, liver failure, and liver cancer. Accordingly, this review summarizes the role of neutrophils in liver diseases. Nature Publishing Group UK 2020-11-06 2021-01 /pmc/articles/PMC7852892/ /pubmed/33159158 http://dx.doi.org/10.1038/s41423-020-00560-0 Text en © CSI and USTC 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review Article
Liu, Kai
Wang, Fu-Sheng
Xu, Ruonan
Neutrophils in liver diseases: pathogenesis and therapeutic targets
title Neutrophils in liver diseases: pathogenesis and therapeutic targets
title_full Neutrophils in liver diseases: pathogenesis and therapeutic targets
title_fullStr Neutrophils in liver diseases: pathogenesis and therapeutic targets
title_full_unstemmed Neutrophils in liver diseases: pathogenesis and therapeutic targets
title_short Neutrophils in liver diseases: pathogenesis and therapeutic targets
title_sort neutrophils in liver diseases: pathogenesis and therapeutic targets
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7852892/
https://www.ncbi.nlm.nih.gov/pubmed/33159158
http://dx.doi.org/10.1038/s41423-020-00560-0
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