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Fournier’s gangrene with dapagliflozin in a rural hospital: a case report
Sodium-glucose cotransporter 2 (SGLT2) inhibitors, which are used for treatment of type 2 diabetes, are associated with risk of urogenital infections. FDA issued a black box warning about multiple case reports of Fournier’s gangrene (FG) observed in patients taking SGLT2 inhibitors. FG is a type of...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7852914/ https://www.ncbi.nlm.nih.gov/pubmed/33526523 http://dx.doi.org/10.1136/bcr-2020-237784 |
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author | Elbeddini, Ali Tayefehchamani, Yasamin Davey, Michelle Gallinger, Jodi Hooda, Naushin Aly, Ahmed Erickson, Dawn Lee, Stephanie |
author_facet | Elbeddini, Ali Tayefehchamani, Yasamin Davey, Michelle Gallinger, Jodi Hooda, Naushin Aly, Ahmed Erickson, Dawn Lee, Stephanie |
author_sort | Elbeddini, Ali |
collection | PubMed |
description | Sodium-glucose cotransporter 2 (SGLT2) inhibitors, which are used for treatment of type 2 diabetes, are associated with risk of urogenital infections. FDA issued a black box warning about multiple case reports of Fournier’s gangrene (FG) observed in patients taking SGLT2 inhibitors. FG is a type of necrotising fasciitis that occurs in the anogenital area. We report a case of a 71-year-old woman with type 2 diabetes on dapagliflozin, presenting with foul-smelling discharge and a large abscess in the perianal area. Her risk factors for FG included her advanced age, obesity, diabetes and trauma to the site. During her stay, dapagliflozin was discontinued and she received procedural debridement, wound care and broad-spectrum intravenous antibiotics. Due to possible association between FG and SGLT2 inhibitors, patients presenting with signs and symptoms of FG who are taking SGLT2 inhibitors should be examined for infection in the urogenital area and treated promptly. |
format | Online Article Text |
id | pubmed-7852914 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-78529142021-02-02 Fournier’s gangrene with dapagliflozin in a rural hospital: a case report Elbeddini, Ali Tayefehchamani, Yasamin Davey, Michelle Gallinger, Jodi Hooda, Naushin Aly, Ahmed Erickson, Dawn Lee, Stephanie BMJ Case Rep Case Report Sodium-glucose cotransporter 2 (SGLT2) inhibitors, which are used for treatment of type 2 diabetes, are associated with risk of urogenital infections. FDA issued a black box warning about multiple case reports of Fournier’s gangrene (FG) observed in patients taking SGLT2 inhibitors. FG is a type of necrotising fasciitis that occurs in the anogenital area. We report a case of a 71-year-old woman with type 2 diabetes on dapagliflozin, presenting with foul-smelling discharge and a large abscess in the perianal area. Her risk factors for FG included her advanced age, obesity, diabetes and trauma to the site. During her stay, dapagliflozin was discontinued and she received procedural debridement, wound care and broad-spectrum intravenous antibiotics. Due to possible association between FG and SGLT2 inhibitors, patients presenting with signs and symptoms of FG who are taking SGLT2 inhibitors should be examined for infection in the urogenital area and treated promptly. BMJ Publishing Group 2021-02-01 /pmc/articles/PMC7852914/ /pubmed/33526523 http://dx.doi.org/10.1136/bcr-2020-237784 Text en © BMJ Publishing Group Limited 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Case Report Elbeddini, Ali Tayefehchamani, Yasamin Davey, Michelle Gallinger, Jodi Hooda, Naushin Aly, Ahmed Erickson, Dawn Lee, Stephanie Fournier’s gangrene with dapagliflozin in a rural hospital: a case report |
title | Fournier’s gangrene with dapagliflozin in a rural hospital: a case report |
title_full | Fournier’s gangrene with dapagliflozin in a rural hospital: a case report |
title_fullStr | Fournier’s gangrene with dapagliflozin in a rural hospital: a case report |
title_full_unstemmed | Fournier’s gangrene with dapagliflozin in a rural hospital: a case report |
title_short | Fournier’s gangrene with dapagliflozin in a rural hospital: a case report |
title_sort | fournier’s gangrene with dapagliflozin in a rural hospital: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7852914/ https://www.ncbi.nlm.nih.gov/pubmed/33526523 http://dx.doi.org/10.1136/bcr-2020-237784 |
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