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Loss of Ryanodine Receptor 2 impairs neuronal activity-dependent remodeling of dendritic spines and triggers compensatory neuronal hyperexcitability

Dendritic spines are postsynaptic domains that shape structural and functional properties of neurons. Upon neuronal activity, Ca(2+) transients trigger signaling cascades that determine the plastic remodeling of dendritic spines, which modulate learning and memory. Here, we study in mice the role of...

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Detalles Bibliográficos
Autores principales:	Bertan, Fabio, Wischhof, Lena, Sosulina, Liudmila, Mittag, Manuel, Dalügge, Dennis, Fornarelli, Alessandra, Gardoni, Fabrizio, Marcello, Elena, Di Luca, Monica, Fuhrmann, Martin, Remy, Stefan, Bano, Daniele, Nicotera, Pierluigi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7853040/ https://www.ncbi.nlm.nih.gov/pubmed/32641776 http://dx.doi.org/10.1038/s41418-020-0584-2

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