Loss of p53 in mesenchymal stem cells promotes alteration of bone remodeling through negative regulation of osteoprotegerin

p53 plays a pivotal role in controlling the differentiation of mesenchymal stem cells (MSCs) by regulating genes involved in cell cycle and early steps of differentiation process. In the context of osteogenic differentiation of MSCs and bone homeostasis, the osteoprotegerin/receptor activator of NF-...

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Detalles Bibliográficos
Autores principales: Velletri, Tania, Huang, Yin, Wang, Yu, Li, Qing, Hu, Mingyuan, Xie, Ningxia, Yang, Qian, Chen, Xiaodong, Chen, Qing, Shou, Peishun, Gan, Yurun, Candi, Eleonora, Annicchiarico-Petruzzelli, Margherita, Agostini, Massimiliano, Yang, Huilin, Melino, Gerry, Shi, Yufang, Wang, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7853126/
https://www.ncbi.nlm.nih.gov/pubmed/32694652
http://dx.doi.org/10.1038/s41418-020-0590-4

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