Cargando…

A multicentre, randomised, open-label, parallel-group Phase 2b study of belotecan versus topotecan for recurrent ovarian cancer

BACKGROUND: This Phase 2b study compared the efficacy and toxicity of belotecan and topotecan in recurrent ovarian cancer. METHODS: Patients with platinum-sensitive recurrent or platinum-resistant recurrent ovarian cancer (PRROC) were randomised 1:1 to receive belotecan 0.5 mg/m(2) or topotecan 1.5 ...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Hee Seung, Park, Sang-Yoon, Park, Chan-Yong, Kim, Young Tae, Kim, Beob-Jong, Song, Yong Jung, Kim, Byoung-Gie, Kim, Yong Beom, Cho, Chi-Heum, Kim, Jong-Hyeok, Song, Yong Sang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7853132/ https://www.ncbi.nlm.nih.gov/pubmed/32994466 http://dx.doi.org/10.1038/s41416-020-01098-8

Ejemplares similares

A randomised phase 2b study comparing the efficacy and safety of belotecan vs. topotecan as monotherapy for sensitive-relapsed small-cell lung cancer
por: Kang, Jin-Hyoung, et al.
Publicado: (2020)

Synergism of AZD6738, an ATR Inhibitor, in Combination with Belotecan, a Camptothecin Analogue, in Chemotherapy-Resistant Ovarian Cancer
por: Hur, Jin, et al.
Publicado: (2021)

An Open-Label, Randomized, Parallel, Phase II Trial to Evaluate the Efficacy and Safety of a Cremophor-Free Polymeric Micelle Formulation of Paclitaxel as First-Line Treatment for Ovarian Cancer: A Korean Gynecologic Oncology Group Study (KGOG-3021)
por: Lee, Shin-Wha, et al.
Publicado: (2018)

Ovarian Gynandroblastoma with a Juvenile Granulosa Cell Tumor Component in a Postmenopausal Woman
por: Hwang, Soohyun, et al.
Publicado: (2020)

Lesser Toxicities of Belotecan in Patients with Small Cell Lung Cancer: A Retrospective Single-Center Study of Camptothecin Analogs
por: Park, Yeon Hee, et al.
Publicado: (2016)

Belotecan/cisplatin versus etoposide/cisplatin in previously untreated patients with extensive-stage small cell lung carcinoma: a multi-center randomized phase III trial
por: Oh, In-Jae, et al.
Publicado: (2016)

2,2′-Methylenebis (6-tert-butyl 4-methylphenol) enhances the antitumor efficacy of belotecan, a derivative of camptothecin, by inducing autophagy
por: Jang, Minsu, et al.
Publicado: (2017)

Stratifying the risk of ovarian cancer incidence by histologic subtypes in the Korean Epithelial Ovarian Cancer Study (Ko‐EVE)
por: Sung, Soseul, et al.
Publicado: (2023)

Biomarker-guided targeted therapy in platinum-resistant ovarian cancer (AMBITION; KGOG 3045): a multicentre, open-label, five-arm, uncontrolled, umbrella trial
por: Lee, Jung-Yun, et al.
Publicado: (2022)

Prevalence and clinical characterization of BRCA1 and BRCA2 mutations in Korean patients with epithelial ovarian cancer
por: Paik, E Sun, et al.
Publicado: (2021)

Long-term efficacy, safety and immunogenicity in patients with rheumatoid arthritis continuing on an etanercept biosimilar (LBEC0101) or switching from reference etanercept to LBEC0101: an open-label extension of a phase III multicentre, randomised, double-blind, parallel-group study
por: Park, Min-Chan, et al.
Publicado: (2019)

Expression Profiles of Epithelial-Mesenchymal Transition-Associated Proteins in Epithelial Ovarian Carcinoma
por: Kim, Mi-Kyung, et al.
Publicado: (2014)

Multivariable index for assessing the activity and predicting all‐cause mortality in antineutrophil cytoplasmic antibody‐associated vasculitis
por: Kim, Minyoung Kevin, et al.
Publicado: (2019)

Topotecan-Based Combination Chemotherapy in Patients with Transformed Chronic Myelogenous Leukemia and Advanced Myelodysplastic Syndrome
por: Park, Soo Jeong, et al.
Publicado: (2000)

Reexamination of Dopaminergic Amacrine Cells in the Rabbit Retina: Confocal Analysis with Double- and Triple-labeling Immunohistochemistry
por: Lee, Jong Woo, et al.
Publicado: (2017)

Rituximab Biosimilar Prevents Poor Outcomes of Microscopic Polyangiitis and Granulomatosis with Polyangiitis as Effectively as Rituximab Originator
por: Kwon, Hyeok Chan, et al.
Publicado: (2020)

Antineutrophil Cytoplasmic Antibody Positivity Is Associated with Vascular Involvement in Behçet's Disease
por: Kim, Minyoung Kevin, et al.
Publicado: (2021)

A randomized, open-label, parallel, multi-center Phase IV study to compare the efficacy and safety of atorvastatin 10 and 20 mg in high-risk Asian patients with hypercholesterolemia
por: Kim, Ji Bak, et al.
Publicado: (2021)

Correction: A randomized, open-label, parallel, multi-center Phase IV study to compare the efficacy and safety of atorvastatin 10 and 20 mg in high-risk Asian patients with hypercholesterolemia
por: Kim, Ji Bak, et al.
Publicado: (2021)

ERRATUM: Acknowledgments Correction. Cell-Free miR-27a, a Potential Diagnostic and Prognostic Biomarker for Gastric Cancer
por: Park, Jong-Lyul, et al.
Publicado: (2015)

Cell-Free miR-27a, a Potential Diagnostic and Prognostic Biomarker for Gastric Cancer
por: Park, Jong-Lyul, et al.
Publicado: (2015)

Evaluation of wet-cupping therapy for persistent non-specific low back pain: a randomised, waiting-list controlled, open-label, parallel-group pilot trial
por: Kim, Jong-In, et al.
Publicado: (2011)

Phase II Study to Topotecan and Cisplatin in Advanced Hepatocellular Carcinoma
por: Lee, Ga Young, et al.
Publicado: (2003)

Targeting Nrf2 Signaling to Combat Chemoresistance
por: No, Jae Hong, et al.
Publicado: (2014)

Improvements to the FIGO staging for ovarian cancer: reconsideration of lymphatic spread and intraoperative tumor rupture
por: Suh, Dong Hoon, et al.
Publicado: (2013)

Effect of Squat Exercises on Lung Function in Elderly Women with Sarcopenia
por: Jeon, Yun Kyung, et al.
Publicado: (2018)

Real-World Experience of Olaparib Maintenance in High-Grade Serous Recurrent Ovarian Cancer Patients with BRCA1/2 Mutation: A Korean Multicenter Study
por: Paik, E Sun, et al.
Publicado: (2019)

Comparison of outcomes between radical hysterectomy followed by tailored adjuvant therapy versus primary chemoradiation therapy in IB2 and IIA2 cervical cancer
por: Park, Jeong-Yeol, et al.
Publicado: (2012)

The first human case of hepatic dirofilariasis.
por: Kim, Min Kyung, et al.
Publicado: (2002)

STK31 upregulation is associated with chromatin remodeling in gastric cancer and induction of tumorigenicity in a xenograft mouse model
por: Bae, Dong Hyuck, et al.
Publicado: (2021)

ONECUT2 upregulation is associated with CpG hypomethylation at promoter‐proximal DNA in gastric cancer and triggers ACSL5
por: Seo, Eun‐Hye, et al.
Publicado: (2020)

Prediction of a high-risk group based on postoperative nadir CA-125 levels in patients with advanced epithelial ovarian cancer
por: Kang, Sokbom, et al.
Publicado: (2011)

Management of endoscopic retrograde cholangiopancreatography-related perforations
por: Kim, Byung Seup, et al.
Publicado: (2011)

Efficacy and safety of Lenzumestrocel (Neuronata-R® inj.) in patients with amyotrophic lateral sclerosis (ALSUMMIT study): study protocol for a multicentre, randomized, double-blind, parallel-group, sham procedure-controlled, phase III trial
por: Nam, Jae-Yong, et al.
Publicado: (2022)

Ascites modulates cancer cell behavior, contributing to tumor heterogeneity in ovarian cancer
por: Kim, Soochi, et al.
Publicado: (2016)

Aberrant Methylation of Somatostatin Receptor 2 Gene Is Initiated in Aged Gastric Mucosa Infected with Helicobacter pylori and Consequential Gene Silencing Is Associated with Establishment of Inflammatory Microenvironment In Vitro Study
por: Kim, Hee-Jin, et al.
Publicado: (2022)

Is nutritional labeling associated with individual health? The effects of labeling-based awareness on dyslipidemia risk in a South Korean population
por: Kim, Jong Yeob, et al.
Publicado: (2016)

Synchronous gynecologic malignancy and preliminary results of Lynch syndrome
por: Kim, Min Kyu, et al.
Publicado: (2011)

Nutrient digestibility in black soldier fly larva was greater than in adults for pigs and could be estimated using fiber
por: Kim, Jongkeon, et al.
Publicado: (2023)

Difference of Diagnostic Rates and Analytical Methods in the Test Positions of Vestibular Evoked Myogenic Potentials
por: Kim, Ji Hyun, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_gqe37i8crkr028250ucjhirkgk