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Neuroimaging Detectable Differences between Parkinson's Disease Motor Subtypes: A Systematic Review

BACKGROUND: The neuroanatomical substrates of Parkinson's disease (PD) with tremor‐dominance (TD) and those with non‐tremor dominance (nTD), postural instability and gait difficulty (PIGD), and akinetic‐rigid (AR) are not fully differentiated. A better understanding of symptom specific pathoana...

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Autores principales: Boonstra, Jackson Tyler, Michielse, Stijn, Temel, Yasin, Hoogland, Govert, Jahanshahi, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7853198/
https://www.ncbi.nlm.nih.gov/pubmed/33553487
http://dx.doi.org/10.1002/mdc3.13107
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author Boonstra, Jackson Tyler
Michielse, Stijn
Temel, Yasin
Hoogland, Govert
Jahanshahi, Ali
author_facet Boonstra, Jackson Tyler
Michielse, Stijn
Temel, Yasin
Hoogland, Govert
Jahanshahi, Ali
author_sort Boonstra, Jackson Tyler
collection PubMed
description BACKGROUND: The neuroanatomical substrates of Parkinson's disease (PD) with tremor‐dominance (TD) and those with non‐tremor dominance (nTD), postural instability and gait difficulty (PIGD), and akinetic‐rigid (AR) are not fully differentiated. A better understanding of symptom specific pathoanatomical markers of PD subtypes may result in earlier diagnosis and more tailored treatment. Here, we aim to give an overview of the neuroimaging literature that compared PD motor subtypes. METHODS: A systematic literature review on neuroimaging studies of PD subtypes was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) guidelines. Search terms submitted to the PubMed database included: “Parkinson's disease”, “MRI” and “motor subtypes” (TD, nTD, PIGD, AR). The results are first discussed from macro to micro level of organization (i.e., (1) structural; (2) functional; and (3) molecular) and then by applied imaging methodology. FINDINGS: Several neuroimaging methods including diffusion imaging and positron emission tomography (PET) distinguish specific PD motor subtypes well, although findings are mixed. Furthermore, our review demonstrates that nTD‐PD patients have more severe neuroalterations compared to TD‐PD patients. More specifically, nTD‐PD patients have deficits within striato‐thalamo‐cortical (STC) circuitry and other thalamocortical projections related to cognitive and sensorimotor function, while TD‐PD patients tend to have greater cerebello‐thalamo‐cortical (CTC) circuitry dysfunction. CONCLUSIONS: Based on the literature, STC and CTC circuitry deficits seem to be the key features of PD and the subtypes. Future research should make greater use of multimodal neuroimaging and techniques that have higher sensitivity in delineating subcortical structures involved in motor diseases.
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spelling pubmed-78531982021-02-05 Neuroimaging Detectable Differences between Parkinson's Disease Motor Subtypes: A Systematic Review Boonstra, Jackson Tyler Michielse, Stijn Temel, Yasin Hoogland, Govert Jahanshahi, Ali Mov Disord Clin Pract Reviews BACKGROUND: The neuroanatomical substrates of Parkinson's disease (PD) with tremor‐dominance (TD) and those with non‐tremor dominance (nTD), postural instability and gait difficulty (PIGD), and akinetic‐rigid (AR) are not fully differentiated. A better understanding of symptom specific pathoanatomical markers of PD subtypes may result in earlier diagnosis and more tailored treatment. Here, we aim to give an overview of the neuroimaging literature that compared PD motor subtypes. METHODS: A systematic literature review on neuroimaging studies of PD subtypes was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) guidelines. Search terms submitted to the PubMed database included: “Parkinson's disease”, “MRI” and “motor subtypes” (TD, nTD, PIGD, AR). The results are first discussed from macro to micro level of organization (i.e., (1) structural; (2) functional; and (3) molecular) and then by applied imaging methodology. FINDINGS: Several neuroimaging methods including diffusion imaging and positron emission tomography (PET) distinguish specific PD motor subtypes well, although findings are mixed. Furthermore, our review demonstrates that nTD‐PD patients have more severe neuroalterations compared to TD‐PD patients. More specifically, nTD‐PD patients have deficits within striato‐thalamo‐cortical (STC) circuitry and other thalamocortical projections related to cognitive and sensorimotor function, while TD‐PD patients tend to have greater cerebello‐thalamo‐cortical (CTC) circuitry dysfunction. CONCLUSIONS: Based on the literature, STC and CTC circuitry deficits seem to be the key features of PD and the subtypes. Future research should make greater use of multimodal neuroimaging and techniques that have higher sensitivity in delineating subcortical structures involved in motor diseases. John Wiley & Sons, Inc. 2020-11-06 /pmc/articles/PMC7853198/ /pubmed/33553487 http://dx.doi.org/10.1002/mdc3.13107 Text en © 2020 The Authors. Movement Disorders Clinical Practice published by Wiley Periodicals LLC. on behalf of International Parkinson and Movement Disorder Society. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Boonstra, Jackson Tyler
Michielse, Stijn
Temel, Yasin
Hoogland, Govert
Jahanshahi, Ali
Neuroimaging Detectable Differences between Parkinson's Disease Motor Subtypes: A Systematic Review
title Neuroimaging Detectable Differences between Parkinson's Disease Motor Subtypes: A Systematic Review
title_full Neuroimaging Detectable Differences between Parkinson's Disease Motor Subtypes: A Systematic Review
title_fullStr Neuroimaging Detectable Differences between Parkinson's Disease Motor Subtypes: A Systematic Review
title_full_unstemmed Neuroimaging Detectable Differences between Parkinson's Disease Motor Subtypes: A Systematic Review
title_short Neuroimaging Detectable Differences between Parkinson's Disease Motor Subtypes: A Systematic Review
title_sort neuroimaging detectable differences between parkinson's disease motor subtypes: a systematic review
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7853198/
https://www.ncbi.nlm.nih.gov/pubmed/33553487
http://dx.doi.org/10.1002/mdc3.13107
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