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Inositol phosphates promote HIV-1 assembly and maturation to facilitate viral spread in human CD4(+) T cells
Gag polymerization with viral RNA at the plasma membrane initiates HIV-1 assembly. Assembly processes are inefficient in vitro but are stimulated by inositol (1,3,4,5,6) pentakisphosphate (IP5) and inositol hexakisphosphate (IP6) metabolites. Previous studies have shown that depletion of these inosi...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7853515/ https://www.ncbi.nlm.nih.gov/pubmed/33476323 http://dx.doi.org/10.1371/journal.ppat.1009190 |