Cargando…

Long-Term Humoral Immune Response in Persons with Asymptomatic or Mild SARS-CoV-2 Infection, Vietnam

Antibody response against nucleocapsid and spike proteins of SARS-CoV-2 in 11 persons with mild or asymptomatic infection rapidly increased after infection. At weeks 18–30 after diagnosis, all remained seropositive but spike protein–targeting antibody titers declined. These data may be useful for va...

Descripción completa

Detalles Bibliográficos
Autores principales: Mai, Huynh Kim, Trieu, Nguyen Bao, Long, Trinh Hoang, Thanh, Hoang Tien, Luong, Nguyen Dinh, Huy, Le Xuan, Nguyet, Lam Anh, Man, Dinh Nguyen Huy, Anderson, Danielle E., Thanh, Tran Tan, Chau, Nguyen Van Vinh, Thwaites, Guy, Wang, Lin-Fa, Van Tan, Le, Hung, Do Thai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7853537/
https://www.ncbi.nlm.nih.gov/pubmed/33496647
http://dx.doi.org/10.3201/eid2702.204226
_version_ 1783645982280384512
author Mai, Huynh Kim
Trieu, Nguyen Bao
Long, Trinh Hoang
Thanh, Hoang Tien
Luong, Nguyen Dinh
Huy, Le Xuan
Nguyet, Lam Anh
Man, Dinh Nguyen Huy
Anderson, Danielle E.
Thanh, Tran Tan
Chau, Nguyen Van Vinh
Thwaites, Guy
Wang, Lin-Fa
Van Tan, Le
Hung, Do Thai
author_facet Mai, Huynh Kim
Trieu, Nguyen Bao
Long, Trinh Hoang
Thanh, Hoang Tien
Luong, Nguyen Dinh
Huy, Le Xuan
Nguyet, Lam Anh
Man, Dinh Nguyen Huy
Anderson, Danielle E.
Thanh, Tran Tan
Chau, Nguyen Van Vinh
Thwaites, Guy
Wang, Lin-Fa
Van Tan, Le
Hung, Do Thai
author_sort Mai, Huynh Kim
collection PubMed
description Antibody response against nucleocapsid and spike proteins of SARS-CoV-2 in 11 persons with mild or asymptomatic infection rapidly increased after infection. At weeks 18–30 after diagnosis, all remained seropositive but spike protein–targeting antibody titers declined. These data may be useful for vaccine development.
format Online
Article
Text
id pubmed-7853537
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Centers for Disease Control and Prevention
record_format MEDLINE/PubMed
spelling pubmed-78535372021-02-09 Long-Term Humoral Immune Response in Persons with Asymptomatic or Mild SARS-CoV-2 Infection, Vietnam Mai, Huynh Kim Trieu, Nguyen Bao Long, Trinh Hoang Thanh, Hoang Tien Luong, Nguyen Dinh Huy, Le Xuan Nguyet, Lam Anh Man, Dinh Nguyen Huy Anderson, Danielle E. Thanh, Tran Tan Chau, Nguyen Van Vinh Thwaites, Guy Wang, Lin-Fa Van Tan, Le Hung, Do Thai Emerg Infect Dis Research Letter Antibody response against nucleocapsid and spike proteins of SARS-CoV-2 in 11 persons with mild or asymptomatic infection rapidly increased after infection. At weeks 18–30 after diagnosis, all remained seropositive but spike protein–targeting antibody titers declined. These data may be useful for vaccine development. Centers for Disease Control and Prevention 2021-02 /pmc/articles/PMC7853537/ /pubmed/33496647 http://dx.doi.org/10.3201/eid2702.204226 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research Letter
Mai, Huynh Kim
Trieu, Nguyen Bao
Long, Trinh Hoang
Thanh, Hoang Tien
Luong, Nguyen Dinh
Huy, Le Xuan
Nguyet, Lam Anh
Man, Dinh Nguyen Huy
Anderson, Danielle E.
Thanh, Tran Tan
Chau, Nguyen Van Vinh
Thwaites, Guy
Wang, Lin-Fa
Van Tan, Le
Hung, Do Thai
Long-Term Humoral Immune Response in Persons with Asymptomatic or Mild SARS-CoV-2 Infection, Vietnam
title Long-Term Humoral Immune Response in Persons with Asymptomatic or Mild SARS-CoV-2 Infection, Vietnam
title_full Long-Term Humoral Immune Response in Persons with Asymptomatic or Mild SARS-CoV-2 Infection, Vietnam
title_fullStr Long-Term Humoral Immune Response in Persons with Asymptomatic or Mild SARS-CoV-2 Infection, Vietnam
title_full_unstemmed Long-Term Humoral Immune Response in Persons with Asymptomatic or Mild SARS-CoV-2 Infection, Vietnam
title_short Long-Term Humoral Immune Response in Persons with Asymptomatic or Mild SARS-CoV-2 Infection, Vietnam
title_sort long-term humoral immune response in persons with asymptomatic or mild sars-cov-2 infection, vietnam
topic Research Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7853537/
https://www.ncbi.nlm.nih.gov/pubmed/33496647
http://dx.doi.org/10.3201/eid2702.204226
work_keys_str_mv AT maihuynhkim longtermhumoralimmuneresponseinpersonswithasymptomaticormildsarscov2infectionvietnam
AT trieunguyenbao longtermhumoralimmuneresponseinpersonswithasymptomaticormildsarscov2infectionvietnam
AT longtrinhhoang longtermhumoralimmuneresponseinpersonswithasymptomaticormildsarscov2infectionvietnam
AT thanhhoangtien longtermhumoralimmuneresponseinpersonswithasymptomaticormildsarscov2infectionvietnam
AT luongnguyendinh longtermhumoralimmuneresponseinpersonswithasymptomaticormildsarscov2infectionvietnam
AT huylexuan longtermhumoralimmuneresponseinpersonswithasymptomaticormildsarscov2infectionvietnam
AT nguyetlamanh longtermhumoralimmuneresponseinpersonswithasymptomaticormildsarscov2infectionvietnam
AT mandinhnguyenhuy longtermhumoralimmuneresponseinpersonswithasymptomaticormildsarscov2infectionvietnam
AT andersondaniellee longtermhumoralimmuneresponseinpersonswithasymptomaticormildsarscov2infectionvietnam
AT thanhtrantan longtermhumoralimmuneresponseinpersonswithasymptomaticormildsarscov2infectionvietnam
AT chaunguyenvanvinh longtermhumoralimmuneresponseinpersonswithasymptomaticormildsarscov2infectionvietnam
AT thwaitesguy longtermhumoralimmuneresponseinpersonswithasymptomaticormildsarscov2infectionvietnam
AT wanglinfa longtermhumoralimmuneresponseinpersonswithasymptomaticormildsarscov2infectionvietnam
AT vantanle longtermhumoralimmuneresponseinpersonswithasymptomaticormildsarscov2infectionvietnam
AT hungdothai longtermhumoralimmuneresponseinpersonswithasymptomaticormildsarscov2infectionvietnam