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Dose- and time-dependent tolerability and efficacy of organo-osmium complex FY26 and its tissue pharmacokinetics in hepatocarcinoma-bearing mice

The organo-osmium complex [Os(II)(ɳ(6)-p-cym)(PhAzPy-NMe(2))I](+) (FY26) exhibits promising in vitro antitumour activity against mouse hepatocarcinoma Hepa1–6 and other mouse or human cancer cell lines. Here, we drastically enhance water solubility of FY26 through the replacement of the PF(6)(−) cou...

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Detalles Bibliográficos
Autores principales:	Kumar, Swati A, Needham, Russell J, Abraham, Kristin, Bridgewater, Hannah E, Garbutt, Lauren A, Xandri-Monje, Helena, Dallmann, Robert, Perrier, Sebastien, Sadler, Peter J, Lévi, Francis
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7853623/ https://www.ncbi.nlm.nih.gov/pubmed/33595653 http://dx.doi.org/10.1093/mtomcs/mfaa003

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