A small-molecule ICMT inhibitor delays senescence of Hutchinson-Gilford progeria syndrome cells

A farnesylated and methylated form of prelamin A called progerin causes Hutchinson-Gilford progeria syndrome (HGPS). Inhibiting progerin methylation by inactivating the isoprenylcysteine carboxylmethyltransferase (ICMT) gene stimulates proliferation of HGPS cells and improves survival of Zmpste24-de...

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Detalles Bibliográficos
Autores principales: Chen, Xue, Yao, Haidong, Kashif, Muhammad, Revêchon, Gwladys, Eriksson, Maria, Hu, Jianjiang, Wang, Ting, Liu, Yiran, Tüksammel, Elin, Strömblad, Staffan, Ahearn, Ian M, Philips, Mark R, Wiel, Clotilde, Ibrahim, Mohamed X, Bergo, Martin O
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7853716/
https://www.ncbi.nlm.nih.gov/pubmed/33526168
http://dx.doi.org/10.7554/eLife.63284

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