Anti-tau scFvs Targeted to the Cytoplasm or Secretory Pathway Variably Modify Pathology and Neurodegenerative Phenotypes

Immunotherapies designed to treat neurodegenerative tauopathies that primarily engage extracellular tau may have limited efficacy as tau is primarily intracellular. We generated tau-targeting single-chain variable fragments (scFvs) and intrabodies (iBs) from the phosphorylated tau-specific antibodie...

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Detalles Bibliográficos
Autores principales: Goodwin, Marshall S., Sinyavskaya, Olga, Burg, Franklin, O’Neal, Veronica, Ceballos-Diaz, Carolina, Cruz, Pedro E., Lewis, Jada, Giasson, Benoit I., Davies, Peter, Golde, Todd E., Levites, Yona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7854277/
https://www.ncbi.nlm.nih.gov/pubmed/33128896
http://dx.doi.org/10.1016/j.ymthe.2020.10.007

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