Cargando…

Efficient Gene Suppression by DNA/DNA Double-Stranded Oligonucleotide In Vivo

We recently reported the antisense properties of a DNA/RNA heteroduplex oligonucleotide consisting of a phosphorothioate DNA-gapmer antisense oligonucleotide (ASO) strand and its complementary phosphodiester RNA/phosphorothioate 2′-O-methyl RNA strand. When α-tocopherol was conjugated with the compl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Asami, Yutaro, Nagata, Tetsuya, Yoshioka, Kotaro, Kunieda, Taiki, Yoshida-Tanaka, Kie, Bennett, C. Frank, Seth, Punit P., Yokota, Takanori
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7854292/ https://www.ncbi.nlm.nih.gov/pubmed/33290725 http://dx.doi.org/10.1016/j.ymthe.2020.10.017

Ejemplares similares

Highly efficient silencing of microRNA by heteroduplex oligonucleotides
por: Yoshioka, Kotaro, et al.
Publicado: (2019)

DNA/RNA heteroduplex oligonucleotide for highly efficient gene silencing
por: Nishina, Kazutaka, et al.
Publicado: (2015)

DNA/RNA heteroduplex oligonucleotide technology for regulating lymphocytes in vivo
por: Ohyagi, Masaki, et al.
Publicado: (2021)

Change of intracellular calcium level causes acute neurotoxicity by antisense oligonucleotides via CSF route
por: Jia, Chunyan, et al.
Publicado: (2022)

Separation-related rapid nuclear transport of DNA/RNA heteroduplex oligonucleotide: unveiling distinctive intracellular trafficking
por: Ono, Daisuke, et al.
Publicado: (2020)

Short DNA/RNA heteroduplex oligonucleotide interacting proteins are key regulators of target gene silencing
por: Asada, Ken, et al.
Publicado: (2021)

Effects of combinations of gapmer antisense oligonucleotides on the target reduction
por: Yanagidaira, Mitsugu, et al.
Publicado: (2023)

Systemic DNA/RNA heteroduplex oligonucleotide administration for regulating the gene expression of dorsal root ganglion and sciatic nerve
por: Kaburagi, Hidetoshi, et al.
Publicado: (2022)

Modulation of blood-brain barrier function by a heteroduplex oligonucleotide in vivo
por: Kuwahara, Hiroya, et al.
Publicado: (2018)

In vitro selection of oligonucleotides that bind double-stranded DNA in the presence of triplex-stabilizing agents
por: Ayel, Elodie, et al.
Publicado: (2010)

Stability of double-stranded oligonucleotide DNA with a bulged loop: a microarray study
por: Trapp, Christian, et al.
Publicado: (2011)

Analysis of Guanine Oxidation Products in Double-Stranded DNA and Proposed Guanine Oxidation Pathways in Single-Stranded, Double-Stranded or Quadruplex DNA
por: Morikawa, Masayuki, et al.
Publicado: (2014)

Continuous nonenzymatic cross-replication of DNA strands with in situ activated DNA oligonucleotides
por: Edeleva, Evgeniia, et al.
Publicado: (2019)

Effective silencing of miR-126 after ischemic stroke by means of intravenous α-tocopherol–conjugated heteroduplex oligonucleotide in mice
por: Suzuki, Motohiro, et al.
Publicado: (2021)

Triplex-forming oligonucleotides: a third strand for DNA nanotechnology
por: Chandrasekaran, Arun Richard, et al.
Publicado: (2018)

Strand bias influences the mechanism of gene editing directed by single-stranded DNA oligonucleotides
por: Falgowski, Kerry, et al.
Publicado: (2011)

Chimeric Antisense Oligonucleotide Conjugated to α-Tocopherol
por: Nishina, Tomoko, et al.
Publicado: (2015)

RecA-independent single-stranded DNA oligonucleotide-mediated mutagenesis
por: Murphy, Kenan C, et al.
Publicado: (2010)

Pharmacokinetics and Toxicity in Rats and Monkeys of coDbait: A Therapeutic Double-stranded DNA Oligonucleotide Conjugated to Cholesterol
por: Schlegel, Anne, et al.
Publicado: (2012)

Double-stranded DNA-templated cleavage of oligonucleotides containing a P3′→N5′ linkage triggered by triplex formation: the effects of chemical modifications and remarkable enhancement in reactivity
por: Ito, Kosuke Ramon, et al.
Publicado: (2010)

The Moss Physcomitrella patens Is Hyperresistant to DNA Double-Strand Breaks Induced by γ-Irradiation
por: Yokota, Yuichiro, et al.
Publicado: (2018)

Starting and stopping RNA polymerase III transcription on single-stranded DNA oligonucleotides
por: Lama, Lodoe, et al.
Publicado: (2022)

Production of Double-stranded DNA Ministrings
por: Wong, Shirley, et al.
Publicado: (2016)

Protected DNA strand displacement for enhanced single nucleotide discrimination in double-stranded DNA
por: Khodakov, Dmitriy A., et al.
Publicado: (2015)

Guidelines for Experiments Using Antisense Oligonucleotides and Double-Stranded RNAs
por: Gagnon, Keith T., et al.
Publicado: (2019)

Double‐Strand Breaks in Genome‐Sized DNA Caused by Ultrasound
por: Kubota, Rinko, et al.
Publicado: (2017)

Optimizing anti-gene oligonucleotide ‘Zorro-LNA’ for improved strand invasion into duplex DNA
por: Zaghloul, Eman M., et al.
Publicado: (2011)

Development and antitumor activity of a BCL-2 targeted single-stranded DNA oligonucleotide
por: Rodrigueza, Wendi V., et al.
Publicado: (2014)

The ubiquitin landscape at DNA double-strand breaks
por: Messick, Troy E., et al.
Publicado: (2009)

Nucleolar responses to DNA double-strand breaks
por: Larsen, Dorthe Helena, et al.
Publicado: (2016)

Repair of DNA Double-Strand Breaks in Heterochromatin
por: Watts, Felicity Z.
Publicado: (2016)

Physiological Roles of DNA Double-Strand Breaks
por: Khan, Farhaan A., et al.
Publicado: (2017)

Boon and Bane of DNA Double-Strand Breaks
por: Schubert, Ingo
Publicado: (2021)

Onset of deaminase APOBEC3B induction in response to DNA double-strand breaks
por: Shimizu, Atsuhiro, et al.
Publicado: (2018)

Mapping of genomic double-strand breaks by ligation of biotinylated oligonucleotides to forum domains: Analysis of the data obtained for human rDNA units
por: Tchurikov, N.A., et al.
Publicado: (2014)

Synthetic double-stranded RNA oligonucleotides are immunostimulatory for chicken spleen cells
por: Villanueva, A.I., et al.
Publicado: (2011)

Dna2 initiates resection at clean DNA double-strand breaks
por: Paudyal, Sharad C., et al.
Publicado: (2017)

Quantification of DNA double‐strand breaks using Geant4‐DNA
por: Chatzipapas, Konstantinos P., et al.
Publicado: (2018)

DNA Double-Strand Break Repairs and Their Application in Plant DNA Integration
por: Shen, Hexi, et al.
Publicado: (2022)

DNA double-strand break end synapsis by DNA loop extrusion
por: Yang, Jin H., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_7m5lolba9m0rnvg1p0lus4ole0