Neoadjuvant Gene-Mediated Cytotoxic Immunotherapy for Non-Small-Cell Lung Cancer: Safety and Immunologic Activity

Gene-mediated cytotoxic immunotherapy (GMCI) is an immuno-oncology approach involving local delivery of a replication-deficient adenovirus expressing herpes simplex thymidine kinase (AdV-tk) followed by anti-herpetic prodrug activation that promotes immunogenic tumor cell death, antigen-presenting c...

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Detalles Bibliográficos
Autores principales: Predina, Jarrod D., Haas, Andrew R., Martinez, Marina, O’Brien, Shaun, Moon, Edmund K., Woodruff, Patrick, Stadanlick, Jason, Corbett, Christopher, Frenzel-Sulyok, Lydia, Bryski, Mitchell G., Eruslanov, Evgeniy, Deshpande, Charuhas, Langer, Corey, Aguilar, Laura K., Guzik, Brian W., Manzanera, Andrea G., Aguilar-Cordova, Estuardo, Singhal, Sunil, Albelda, Steven M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7854297/
https://www.ncbi.nlm.nih.gov/pubmed/33160076
http://dx.doi.org/10.1016/j.ymthe.2020.11.001

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