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The RUNX1/RUNX1T1 network: translating insights into therapeutic options

RUNX1/RUNX1T1 is the most common fusion gene found in acute myeloid leukemia. Seminal contributions by many different research groups have revealed a complex regulatory network promoting leukemic self-renewal and propagation. Perturbation of RUNX1/RUNX1T1 levels and its DNA binding affects chromatin...

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Detalles Bibliográficos
Autores principales:	Swart, Laura E., Heidenreich, Olaf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Science Inc 2021
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7854360/ https://www.ncbi.nlm.nih.gov/pubmed/33217477 http://dx.doi.org/10.1016/j.exphem.2020.11.005

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