Anti-phage serum antibody responses and the outcome of phage therapy

We examined the appearance of serum anti-phage antibodies in 25 patients with chronic sinusitis treated with phage therapy (PT). Approximately 30% of patients with weak antibody responses responded positively to PT, which was similar to the results of treatment achieved in a group of patients with h...

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Detalles Bibliográficos
Autores principales: Łusiak-Szelachowska, M., Międzybrodzki, R., Fortuna, W., Borysowski, J., Górski, Andrzej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2020
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7854414/
https://www.ncbi.nlm.nih.gov/pubmed/33126265
http://dx.doi.org/10.1007/s12223-020-00835-z
Descripción
Sumario:We examined the appearance of serum anti-phage antibodies in 25 patients with chronic sinusitis treated with phage therapy (PT). Approximately 30% of patients with weak antibody responses responded positively to PT, which was similar to the results of treatment achieved in a group of patients with high antibody production. In addition, there was no correlation between antibody level and the outcome of PT. These data, derived from a homogenous group of patients, confirm our earlier findings suggesting that the prognostic significance of serum anti-phage antibodies for the outcome of PT should be determined by relevant clinical trials.

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