Anti-phage serum antibody responses and the outcome of phage therapy

We examined the appearance of serum anti-phage antibodies in 25 patients with chronic sinusitis treated with phage therapy (PT). Approximately 30% of patients with weak antibody responses responded positively to PT, which was similar to the results of treatment achieved in a group of patients with h...

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Autores principales: Łusiak-Szelachowska, M., Międzybrodzki, R., Fortuna, W., Borysowski, J., Górski, Andrzej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2020
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7854414/
https://www.ncbi.nlm.nih.gov/pubmed/33126265
http://dx.doi.org/10.1007/s12223-020-00835-z
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author Łusiak-Szelachowska, M.
Międzybrodzki, R.
Fortuna, W.
Borysowski, J.
Górski, Andrzej
author_facet Łusiak-Szelachowska, M.
Międzybrodzki, R.
Fortuna, W.
Borysowski, J.
Górski, Andrzej
author_sort Łusiak-Szelachowska, M.
collection PubMed
description We examined the appearance of serum anti-phage antibodies in 25 patients with chronic sinusitis treated with phage therapy (PT). Approximately 30% of patients with weak antibody responses responded positively to PT, which was similar to the results of treatment achieved in a group of patients with high antibody production. In addition, there was no correlation between antibody level and the outcome of PT. These data, derived from a homogenous group of patients, confirm our earlier findings suggesting that the prognostic significance of serum anti-phage antibodies for the outcome of PT should be determined by relevant clinical trials.
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spelling pubmed-78544142021-02-08 Anti-phage serum antibody responses and the outcome of phage therapy Łusiak-Szelachowska, M. Międzybrodzki, R. Fortuna, W. Borysowski, J. Górski, Andrzej Folia Microbiol (Praha) Short Communication We examined the appearance of serum anti-phage antibodies in 25 patients with chronic sinusitis treated with phage therapy (PT). Approximately 30% of patients with weak antibody responses responded positively to PT, which was similar to the results of treatment achieved in a group of patients with high antibody production. In addition, there was no correlation between antibody level and the outcome of PT. These data, derived from a homogenous group of patients, confirm our earlier findings suggesting that the prognostic significance of serum anti-phage antibodies for the outcome of PT should be determined by relevant clinical trials. Springer Netherlands 2020-10-30 2021 /pmc/articles/PMC7854414/ /pubmed/33126265 http://dx.doi.org/10.1007/s12223-020-00835-z Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Short Communication
Łusiak-Szelachowska, M.
Międzybrodzki, R.
Fortuna, W.
Borysowski, J.
Górski, Andrzej
Anti-phage serum antibody responses and the outcome of phage therapy
title Anti-phage serum antibody responses and the outcome of phage therapy
title_full Anti-phage serum antibody responses and the outcome of phage therapy
title_fullStr Anti-phage serum antibody responses and the outcome of phage therapy
title_full_unstemmed Anti-phage serum antibody responses and the outcome of phage therapy
title_short Anti-phage serum antibody responses and the outcome of phage therapy
title_sort anti-phage serum antibody responses and the outcome of phage therapy
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7854414/
https://www.ncbi.nlm.nih.gov/pubmed/33126265
http://dx.doi.org/10.1007/s12223-020-00835-z
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