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Network Patterns of Herbal Combinations in Traditional Chinese Clinical Prescriptions

As a well-established multidrug combinations schema, traditional Chinese medicine (herbal prescription) has been used for thousands of years in real-world clinical settings. This paper uses a complex network approach to investigate the regularities underlying multidrug combinations in herbal prescri...

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Autores principales: Wang, Ning, Du, Ninglin, Peng, Yonghong, Yang, Kuo, Shu, Zixin, Chang, Kai, Wu, Di, Yu, Jian, Jia, Caiyan, Zhou, Yana, Li, Xiaodong, Liu, Baoyan, Gao, Zhuye, Zhang, Runshun, Zhou, Xuezhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7854460/
https://www.ncbi.nlm.nih.gov/pubmed/33551800
http://dx.doi.org/10.3389/fphar.2020.590824
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author Wang, Ning
Du, Ninglin
Peng, Yonghong
Yang, Kuo
Shu, Zixin
Chang, Kai
Wu, Di
Yu, Jian
Jia, Caiyan
Zhou, Yana
Li, Xiaodong
Liu, Baoyan
Gao, Zhuye
Zhang, Runshun
Zhou, Xuezhong
author_facet Wang, Ning
Du, Ninglin
Peng, Yonghong
Yang, Kuo
Shu, Zixin
Chang, Kai
Wu, Di
Yu, Jian
Jia, Caiyan
Zhou, Yana
Li, Xiaodong
Liu, Baoyan
Gao, Zhuye
Zhang, Runshun
Zhou, Xuezhong
author_sort Wang, Ning
collection PubMed
description As a well-established multidrug combinations schema, traditional Chinese medicine (herbal prescription) has been used for thousands of years in real-world clinical settings. This paper uses a complex network approach to investigate the regularities underlying multidrug combinations in herbal prescriptions. Using five collected large-scale real-world clinical herbal prescription datasets, we construct five weighted herbal combination networks with herb as nodes and herbal combinational use in herbal prescription as links. We found that the weight distribution of herbal combinations displays a clear power law, which means that most herb pairs were used in low frequency and some herb pairs were used in very high frequency. Furthermore, we found that it displays a clear linear negative correlation between the clustering coefficients and the degree of nodes in the herbal combination network (HCNet). This indicates that hierarchical properties exist in the HCNet. Finally, we investigate the molecular network interaction patterns between herb related target modules (i.e., subnetworks) in herbal prescriptions using a network-based approach and further explore the correlation between the distribution of herb combinations and prescriptions. We found that the more the hierarchical prescription, the better the corresponding effect. The results also reflected a well-recognized principle called “Jun-Chen-Zuo-Shi” in TCM formula theories. This also gives references for multidrug combination development in the field of network pharmacology and provides the guideline for the clinical use of combination therapy for chronic diseases.
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spelling pubmed-78544602021-02-04 Network Patterns of Herbal Combinations in Traditional Chinese Clinical Prescriptions Wang, Ning Du, Ninglin Peng, Yonghong Yang, Kuo Shu, Zixin Chang, Kai Wu, Di Yu, Jian Jia, Caiyan Zhou, Yana Li, Xiaodong Liu, Baoyan Gao, Zhuye Zhang, Runshun Zhou, Xuezhong Front Pharmacol Pharmacology As a well-established multidrug combinations schema, traditional Chinese medicine (herbal prescription) has been used for thousands of years in real-world clinical settings. This paper uses a complex network approach to investigate the regularities underlying multidrug combinations in herbal prescriptions. Using five collected large-scale real-world clinical herbal prescription datasets, we construct five weighted herbal combination networks with herb as nodes and herbal combinational use in herbal prescription as links. We found that the weight distribution of herbal combinations displays a clear power law, which means that most herb pairs were used in low frequency and some herb pairs were used in very high frequency. Furthermore, we found that it displays a clear linear negative correlation between the clustering coefficients and the degree of nodes in the herbal combination network (HCNet). This indicates that hierarchical properties exist in the HCNet. Finally, we investigate the molecular network interaction patterns between herb related target modules (i.e., subnetworks) in herbal prescriptions using a network-based approach and further explore the correlation between the distribution of herb combinations and prescriptions. We found that the more the hierarchical prescription, the better the corresponding effect. The results also reflected a well-recognized principle called “Jun-Chen-Zuo-Shi” in TCM formula theories. This also gives references for multidrug combination development in the field of network pharmacology and provides the guideline for the clinical use of combination therapy for chronic diseases. Frontiers Media S.A. 2021-01-20 /pmc/articles/PMC7854460/ /pubmed/33551800 http://dx.doi.org/10.3389/fphar.2020.590824 Text en Copyright © 2021 Zhou, Wang, Du, Peng, Yang, Shu, Chang, Wu, Yu, Jia, Zhou, Li, Liu, Ye and Zhang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Wang, Ning
Du, Ninglin
Peng, Yonghong
Yang, Kuo
Shu, Zixin
Chang, Kai
Wu, Di
Yu, Jian
Jia, Caiyan
Zhou, Yana
Li, Xiaodong
Liu, Baoyan
Gao, Zhuye
Zhang, Runshun
Zhou, Xuezhong
Network Patterns of Herbal Combinations in Traditional Chinese Clinical Prescriptions
title Network Patterns of Herbal Combinations in Traditional Chinese Clinical Prescriptions
title_full Network Patterns of Herbal Combinations in Traditional Chinese Clinical Prescriptions
title_fullStr Network Patterns of Herbal Combinations in Traditional Chinese Clinical Prescriptions
title_full_unstemmed Network Patterns of Herbal Combinations in Traditional Chinese Clinical Prescriptions
title_short Network Patterns of Herbal Combinations in Traditional Chinese Clinical Prescriptions
title_sort network patterns of herbal combinations in traditional chinese clinical prescriptions
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7854460/
https://www.ncbi.nlm.nih.gov/pubmed/33551800
http://dx.doi.org/10.3389/fphar.2020.590824
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