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Tumor Hypoxia Regulates Immune Escape/Invasion: Influence on Angiogenesis and Potential Impact of Hypoxic Biomarkers on Cancer Therapies
The environmental and metabolic pressures in the tumor microenvironment (TME) play a key role in molding tumor development by impacting the stromal and immune cell fractions, TME composition and activation. Hypoxia triggers a cascade of events that promote tumor growth, enhance resistance to the ant...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7854546/ https://www.ncbi.nlm.nih.gov/pubmed/33552076 http://dx.doi.org/10.3389/fimmu.2020.613114 |
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author | Abou Khouzam, Raefa Brodaczewska, Klaudia Filipiak, Aleksandra Zeinelabdin, Nagwa Ahmed Buart, Stephanie Szczylik, Cezary Kieda, Claudine Chouaib, Salem |
author_facet | Abou Khouzam, Raefa Brodaczewska, Klaudia Filipiak, Aleksandra Zeinelabdin, Nagwa Ahmed Buart, Stephanie Szczylik, Cezary Kieda, Claudine Chouaib, Salem |
author_sort | Abou Khouzam, Raefa |
collection | PubMed |
description | The environmental and metabolic pressures in the tumor microenvironment (TME) play a key role in molding tumor development by impacting the stromal and immune cell fractions, TME composition and activation. Hypoxia triggers a cascade of events that promote tumor growth, enhance resistance to the anti-tumor immune response and instigate tumor angiogenesis. During growth, the developing angiogenesis is pathological and gives rise to a haphazardly shaped and leaky tumor vasculature with abnormal properties. Accordingly, aberrantly vascularized TME induces immunosuppression and maintains a continuous hypoxic state. Normalizing the tumor vasculature to restore its vascular integrity, should hence enhance tumor perfusion, relieving hypoxia, and reshaping anti-tumor immunity. Emerging vascular normalization strategies have a great potential in achieving a stable normalization, resulting in mature and functional blood vessels that alleviate tumor hypoxia. Biomarkers enabling the detection and monitoring of tumor hypoxia could be highly advantageous in aiding the translation of novel normalization strategies to clinical application, alone, or in combination with other treatment modalities, such as immunotherapy. |
format | Online Article Text |
id | pubmed-7854546 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78545462021-02-04 Tumor Hypoxia Regulates Immune Escape/Invasion: Influence on Angiogenesis and Potential Impact of Hypoxic Biomarkers on Cancer Therapies Abou Khouzam, Raefa Brodaczewska, Klaudia Filipiak, Aleksandra Zeinelabdin, Nagwa Ahmed Buart, Stephanie Szczylik, Cezary Kieda, Claudine Chouaib, Salem Front Immunol Immunology The environmental and metabolic pressures in the tumor microenvironment (TME) play a key role in molding tumor development by impacting the stromal and immune cell fractions, TME composition and activation. Hypoxia triggers a cascade of events that promote tumor growth, enhance resistance to the anti-tumor immune response and instigate tumor angiogenesis. During growth, the developing angiogenesis is pathological and gives rise to a haphazardly shaped and leaky tumor vasculature with abnormal properties. Accordingly, aberrantly vascularized TME induces immunosuppression and maintains a continuous hypoxic state. Normalizing the tumor vasculature to restore its vascular integrity, should hence enhance tumor perfusion, relieving hypoxia, and reshaping anti-tumor immunity. Emerging vascular normalization strategies have a great potential in achieving a stable normalization, resulting in mature and functional blood vessels that alleviate tumor hypoxia. Biomarkers enabling the detection and monitoring of tumor hypoxia could be highly advantageous in aiding the translation of novel normalization strategies to clinical application, alone, or in combination with other treatment modalities, such as immunotherapy. Frontiers Media S.A. 2021-01-20 /pmc/articles/PMC7854546/ /pubmed/33552076 http://dx.doi.org/10.3389/fimmu.2020.613114 Text en Copyright © 2021 Abou Khouzam, Brodaczewska, Filipiak, Zeinelabdin, Buart, Szczylik, Kieda and Chouaib http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Abou Khouzam, Raefa Brodaczewska, Klaudia Filipiak, Aleksandra Zeinelabdin, Nagwa Ahmed Buart, Stephanie Szczylik, Cezary Kieda, Claudine Chouaib, Salem Tumor Hypoxia Regulates Immune Escape/Invasion: Influence on Angiogenesis and Potential Impact of Hypoxic Biomarkers on Cancer Therapies |
title | Tumor Hypoxia Regulates Immune Escape/Invasion: Influence on Angiogenesis and Potential Impact of Hypoxic Biomarkers on Cancer Therapies |
title_full | Tumor Hypoxia Regulates Immune Escape/Invasion: Influence on Angiogenesis and Potential Impact of Hypoxic Biomarkers on Cancer Therapies |
title_fullStr | Tumor Hypoxia Regulates Immune Escape/Invasion: Influence on Angiogenesis and Potential Impact of Hypoxic Biomarkers on Cancer Therapies |
title_full_unstemmed | Tumor Hypoxia Regulates Immune Escape/Invasion: Influence on Angiogenesis and Potential Impact of Hypoxic Biomarkers on Cancer Therapies |
title_short | Tumor Hypoxia Regulates Immune Escape/Invasion: Influence on Angiogenesis and Potential Impact of Hypoxic Biomarkers on Cancer Therapies |
title_sort | tumor hypoxia regulates immune escape/invasion: influence on angiogenesis and potential impact of hypoxic biomarkers on cancer therapies |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7854546/ https://www.ncbi.nlm.nih.gov/pubmed/33552076 http://dx.doi.org/10.3389/fimmu.2020.613114 |
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