Nucleic acid binding by SAMHD1 contributes to the antiretroviral activity and is enhanced by the GpsN modification

SAMHD1 impedes infection of myeloid cells and resting T lymphocytes by retroviruses, and the enzymatic activity of the protein—dephosphorylation of deoxynucleotide triphosphates (dNTPs)—implicates enzymatic dNTP depletion in innate antiviral immunity. Here we show that the allosteric binding sites o...

Descripción completa

Detalles Bibliográficos
Autores principales: Yu, Corey H., Bhattacharya, Akash, Persaud, Mirjana, Taylor, Alexander B., Wang, Zhonghua, Bulnes-Ramos, Angel, Xu, Joella, Selyutina, Anastasia, Martinez-Lopez, Alicia, Cano, Kristin, Demeler, Borries, Kim, Baek, Hardies, Stephen C., Diaz-Griffero, Felipe, Ivanov, Dmitri N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7854603/
https://www.ncbi.nlm.nih.gov/pubmed/33531504
http://dx.doi.org/10.1038/s41467-021-21023-8

Ejemplares similares

Ejemplares similares