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Alterations in the gut bacterial microbiome in people with type 2 diabetes mellitus and diabetic retinopathy

Gut bacterial microbiome dysbiosis in type 2 Diabetes Mellitus (T2DM) has been reported, but such an association with Diabetic Retinopathy (DR) is not known. We explored possible link between gut bacterial microbiome dysbiosis and DR. Using fecal samples of healthy controls (HC) and people with T2DM...

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Detalles Bibliográficos
Autores principales: Das, Taraprasad, Jayasudha, Rajagopalaboopathi, Chakravarthy, SamaKalyana, Prashanthi, Gumpili Sai, Bhargava, Archana, Tyagi, Mudit, Rani, Padmaja Kumari, Pappuru, Rajeev Reddy, Sharma, Savitri, Shivaji, Sisinthy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7854632/
https://www.ncbi.nlm.nih.gov/pubmed/33531650
http://dx.doi.org/10.1038/s41598-021-82538-0
Descripción
Sumario:Gut bacterial microbiome dysbiosis in type 2 Diabetes Mellitus (T2DM) has been reported, but such an association with Diabetic Retinopathy (DR) is not known. We explored possible link between gut bacterial microbiome dysbiosis and DR. Using fecal samples of healthy controls (HC) and people with T2DM with/without DR, gut bacterial communities were analysed using 16S rRNA gene sequencing and data analysed using QIIME and R software. Dysbiosis in the gut microbiomes, at phyla and genera level, was observed in people with T2DM and DR compared to HC. People with DR exhibited greater discrimination from HC. Microbiomes of people with T2DM and DR were also significantly different. Both DM and DR microbiomes showed a decrease in anti-inflammatory, probiotic and other bacteria that could be pathogenic, compared to HC, and the observed change was more pronounced in people with DR. This is the first report demonstrating dysbiosis in the gut microbiome (alteration in the diversity and abundance at the phyla and genera level) in people with DR compared to HC. Such studies would help in developing novel and targeted therapies to improve treatment of DR.