m(6)A-induced LINC00958 promotes breast cancer tumorigenesis via the miR-378a-3p/YY1 axis

Increasing evidence demonstrates that long noncoding RNAs (lncRNAs) play critical roles in human breast cancer (BC) tumorigenesis. However, the mechanisms by which lncRNA and N(6)-methyladenosine (m(6)A) regulate BC tumorigenesis are still unclear. In the present research, LINC00958 was markedly ove...

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Autores principales: Rong, Dongwen, Dong, Qian, Qu, Huajun, Deng, Xinna, Gao, Fei, Li, Qingxia, Sun, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7854648/
https://www.ncbi.nlm.nih.gov/pubmed/33531456
http://dx.doi.org/10.1038/s41420-020-00382-z
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author Rong, Dongwen
Dong, Qian
Qu, Huajun
Deng, Xinna
Gao, Fei
Li, Qingxia
Sun, Ping
author_facet Rong, Dongwen
Dong, Qian
Qu, Huajun
Deng, Xinna
Gao, Fei
Li, Qingxia
Sun, Ping
author_sort Rong, Dongwen
collection PubMed
description Increasing evidence demonstrates that long noncoding RNAs (lncRNAs) play critical roles in human breast cancer (BC) tumorigenesis. However, the mechanisms by which lncRNA and N(6)-methyladenosine (m(6)A) regulate BC tumorigenesis are still unclear. In the present research, LINC00958 was markedly overexpressed in BC tissue and cells, and LINC00958 upregulation promoted the tumor progression of BC cells. Mechanistically, m(6)A methyltransferase-like 3 (METTL3) gave rise to the upregulation of LINC00958 by promoting its RNA transcript stability. Moreover, LINC00958 acted as a competitive endogenous RNA for miR-378a-3p to promote YY1. Overall, these data provide novel insight into how m(6)A-mediated LINC00958 regulates BC tumorigenesis.
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spelling pubmed-78546482021-02-11 m(6)A-induced LINC00958 promotes breast cancer tumorigenesis via the miR-378a-3p/YY1 axis Rong, Dongwen Dong, Qian Qu, Huajun Deng, Xinna Gao, Fei Li, Qingxia Sun, Ping Cell Death Discov Article Increasing evidence demonstrates that long noncoding RNAs (lncRNAs) play critical roles in human breast cancer (BC) tumorigenesis. However, the mechanisms by which lncRNA and N(6)-methyladenosine (m(6)A) regulate BC tumorigenesis are still unclear. In the present research, LINC00958 was markedly overexpressed in BC tissue and cells, and LINC00958 upregulation promoted the tumor progression of BC cells. Mechanistically, m(6)A methyltransferase-like 3 (METTL3) gave rise to the upregulation of LINC00958 by promoting its RNA transcript stability. Moreover, LINC00958 acted as a competitive endogenous RNA for miR-378a-3p to promote YY1. Overall, these data provide novel insight into how m(6)A-mediated LINC00958 regulates BC tumorigenesis. Nature Publishing Group UK 2021-02-02 /pmc/articles/PMC7854648/ /pubmed/33531456 http://dx.doi.org/10.1038/s41420-020-00382-z Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Rong, Dongwen
Dong, Qian
Qu, Huajun
Deng, Xinna
Gao, Fei
Li, Qingxia
Sun, Ping
m(6)A-induced LINC00958 promotes breast cancer tumorigenesis via the miR-378a-3p/YY1 axis
title m(6)A-induced LINC00958 promotes breast cancer tumorigenesis via the miR-378a-3p/YY1 axis
title_full m(6)A-induced LINC00958 promotes breast cancer tumorigenesis via the miR-378a-3p/YY1 axis
title_fullStr m(6)A-induced LINC00958 promotes breast cancer tumorigenesis via the miR-378a-3p/YY1 axis
title_full_unstemmed m(6)A-induced LINC00958 promotes breast cancer tumorigenesis via the miR-378a-3p/YY1 axis
title_short m(6)A-induced LINC00958 promotes breast cancer tumorigenesis via the miR-378a-3p/YY1 axis
title_sort m(6)a-induced linc00958 promotes breast cancer tumorigenesis via the mir-378a-3p/yy1 axis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7854648/
https://www.ncbi.nlm.nih.gov/pubmed/33531456
http://dx.doi.org/10.1038/s41420-020-00382-z
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