Cargando…

Structure of papain-like protease from SARS-CoV-2 and its complexes with non-covalent inhibitors

The pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) continues to expand. Papain-like protease (PLpro) is one of two SARS-CoV-2 proteases potentially targetable with antivirals. PLpro is an attractive target because it plays an essential role in cleavage and maturation...

Descripción completa

Detalles Bibliográficos
Autores principales:	Osipiuk, Jerzy, Azizi, Saara-Anne, Dvorkin, Steve, Endres, Michael, Jedrzejczak, Robert, Jones, Krysten A., Kang, Soowon, Kathayat, Rahul S., Kim, Youngchang, Lisnyak, Vladislav G., Maki, Samantha L., Nicolaescu, Vlad, Taylor, Cooper A., Tesar, Christine, Zhang, Yu-An, Zhou, Zhiyao, Randall, Glenn, Michalska, Karolina, Snyder, Scott A., Dickinson, Bryan C., Joachimiak, Andrzej
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7854729/ https://www.ncbi.nlm.nih.gov/pubmed/33531496 http://dx.doi.org/10.1038/s41467-021-21060-3

Ejemplares similares

Tipiracil binds to uridine site and inhibits Nsp15 endoribonuclease NendoU from SARS-CoV-2
por: Kim, Youngchang, et al.
Publicado: (2021)

Dual domain recognition determines SARS-CoV-2 PLpro selectivity for human ISG15 and K48-linked di-ubiquitin
por: Wydorski, Pawel M., et al.
Publicado: (2023)

Dual domain recognition determines SARS-CoV-2 PLpro selectivity for human ISG15 and K48-linked di-ubiquitin
por: Wydorski, Pawel M., et al.
Publicado: (2023)

Crystal structures of SARS-CoV-2 ADP-ribose phosphatase: from the apo form to ligand complexes
por: Michalska, Karolina, et al.
Publicado: (2020)

Crystal structure of Nsp15 endoribonuclease NendoU from SARS‐CoV‐2
por: Kim, Youngchang, et al.
Publicado: (2020)

Structural and biochemical analysis of the metallo‐β‐lactamase L1 from emerging pathogen Stenotrophomonas maltophilia revealed the subtle but distinct di‐metal scaffold for catalytic activity
por: Kim, Youngchang, et al.
Publicado: (2019)

Structure of Apo- and Monometalated Forms of NDM-1—A Highly Potent Carbapenem-Hydrolyzing Metallo-β-Lactamase
por: Kim, Youngchang, et al.
Publicado: (2011)

A microbial sensor for organophosphate hydrolysis exploiting an engineered specificity switch in a transcription factor
por: Jha, Ramesh K., et al.
Publicado: (2016)

Structure and enzymatic characterization of CelD endoglucanase from the anaerobic fungus Piromyces finnis
por: Dementiev, Alexey, et al.
Publicado: (2023)

Potent and Selective Covalent Inhibition of the Papain-like Protease from SARS-CoV-2
por: Sanders, Brian, et al.
Publicado: (2022)

Potent and Selective Covalent Inhibition of the Papain-like Protease from SARS-CoV-2
por: Sanders, Brian, et al.
Publicado: (2022)

A novel transcriptional regulator of L-arabinose utilization in human gut bacteria
por: Chang, Changsoo, et al.
Publicado: (2015)

Potent and selective covalent inhibition of the papain-like protease from SARS-CoV-2
por: Sanders, Brian C., et al.
Publicado: (2023)

Repurposing Known Drugs as Covalent and Non-covalent Inhibitors of the SARS-CoV-2 Papain-Like Protease
por: Delre, Pietro, et al.
Publicado: (2020)

Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of SARS-CoV-2
por: Drayman, Nir, et al.
Publicado: (2021)

Papain Covalently Immobilized on Chitosan–Clay Nanocomposite Films: Application in Synthetic and Real White Wine
por: Benucci, Ilaria, et al.
Publicado: (2020)

Atomistic-Level Description of the Covalent Inhibition of SARS-CoV-2 Papain-like Protease
por: Hognon, Cécilia, et al.
Publicado: (2022)

Parthenolide reveals an allosteric mode to inhibit the deISGylation activity of SARS-CoV‑2 papain-like protease: Parthenolide covalently inhibits papain-like protease
por: Zou, Zhihui, et al.
Publicado: (2022)

Antiviral evaluation of hydroxyethylamine analogs: Inhibitors of SARS-CoV-2 main protease (3CLpro), a virtual screening and simulation approach
por: Gupta, Yash, et al.
Publicado: (2021)

Functional and Structural Characterization of Diverse NfsB Chloramphenicol Reductase Enzymes from Human Pathogens
por: Mullowney, Michael W., et al.
Publicado: (2022)

A Novel Cofactor-binding Mode in Bacterial IMP Dehydrogenases Explains Inhibitor Selectivity
por: Makowska-Grzyska, Magdalena, et al.
Publicado: (2015)

Binding of SARS-CoV Covalent Non-Covalent Inhibitors to the SARS-CoV-2 Papain-Like Protease and Ovarian Tumor Domain Deubiquitinases
por: Sivakumar, Dakshinamurthy, et al.
Publicado: (2021)

2′-O methylation of RNA cap in SARS-CoV-2 captured by serial crystallography
por: Wilamowski, Mateusz, et al.
Publicado: (2021)

Identification of ebselen and its analogues as potent covalent inhibitors of papain-like protease from SARS-CoV-2
por: Weglarz-Tomczak, Ewelina, et al.
Publicado: (2021)

A covalent inhibitor targeting the papain-like protease from SARS-CoV-2 inhibits viral replication
por: Han, Hesong, et al.
Publicado: (2023)

Structure-Based Design of Potent Peptidomimetic Inhibitors Covalently Targeting SARS-CoV-2 Papain-like Protease
por: Wang, Qian, et al.
Publicado: (2023)

ABHD10 is an S-depalmitoylase affecting redox homeostasis through peroxiredoxin-5
por: Cao, Yang, et al.
Publicado: (2019)

The CDI toxin of Yersinia kristensenii is a novel bacterial member of the RNase A superfamily
por: Batot, Gaëlle, et al.
Publicado: (2017)

THE ESTIMATION OF PAPAIN WITH HEMOGLOBIN
por: Anson, M. L.
Publicado: (1937)

Properties and Uses of Papain
Publicado: (1897)

THE REMOVAL OF CARTILAGE MATRIX BY PAPAIN : FACTORS AFFECTING THE DISTRIBUTION OF CRYSTALLINE PAPAIN IN VIVO
por: Potter, J. L., et al.
Publicado: (1960)

The crystal structure of nsp10-nsp16 heterodimer from SARS-CoV-2 in complex with S-adenosylmethionine
por: Rosas-Lemus, Monica, et al.
Publicado: (2020)

Mycobacterium tuberculosis Phe-tRNA synthetase: structural insights into tRNA recognition and aminoacylation
por: Michalska, Karolina, et al.
Publicado: (2021)

THE REMOVAL OF CARTILAGE MATRIX, IN VIVO, BY PAPAIN : IDENTIFICATION OF CRYSTALLINE PAPAIN PROTEASE AS THE CAUSE OF THE PHENOMENON
por: McCluskey, Robert T., et al.
Publicado: (1958)

Applicability of papain solutions in immunohematology
por: Santis, Laís Priscila De, et al.
Publicado: (2019)

Coronavirus Papain-like Peptidases
por: Ratia, Kiira, et al.
Publicado: (2013)

Bisindolylmaleimide IX: A novel anti-SARS-CoV2 agent targeting viral main protease 3CLpro demonstrated by virtual screening pipeline and in-vitro validation assays
por: Gupta, Yash, et al.
Publicado: (2021)

Conservation of the structure and function of bacterial tryptophan synthases
por: Michalska, Karolina, et al.
Publicado: (2019)

3D domain swapping in the TIM barrel of the α subunit of Streptococcus pneumoniae tryptophan synthase
por: Michalska, Karolina, et al.
Publicado: (2020)

Mercapto-pyrimidines are reversible covalent inhibitors of the papain-like protease (PLpro) and inhibit SARS-CoV-2 (SCoV-2) replication
por: Bajaj, Teena, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_33tbmm7o33vaegi85s6keh19ts