Cargando…

Activatable polymer nanoagonist for second near-infrared photothermal immunotherapy of cancer

Nanomedicine in combination with immunotherapy offers opportunities to treat cancer in a safe and effective manner; however, remote control of immune response with spatiotemporal precision remains challenging. We herein report a photothermally activatable polymeric pro-nanoagonist (APNA) that is spe...

Descripción completa

Detalles Bibliográficos
Autores principales: Jiang, Yuyan, Huang, Jiaguo, Xu, Cheng, Pu, Kanyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7854754/
https://www.ncbi.nlm.nih.gov/pubmed/33531498
http://dx.doi.org/10.1038/s41467-021-21047-0
_version_ 1783646150193053696
author Jiang, Yuyan
Huang, Jiaguo
Xu, Cheng
Pu, Kanyi
author_facet Jiang, Yuyan
Huang, Jiaguo
Xu, Cheng
Pu, Kanyi
author_sort Jiang, Yuyan
collection PubMed
description Nanomedicine in combination with immunotherapy offers opportunities to treat cancer in a safe and effective manner; however, remote control of immune response with spatiotemporal precision remains challenging. We herein report a photothermally activatable polymeric pro-nanoagonist (APNA) that is specifically regulated by deep-tissue-penetrating second near-infrared (NIR-II) light for combinational photothermal immunotherapy. APNA is constructed from covalent conjugation of an immunostimulant onto a NIR-II semiconducting transducer through a labile thermo-responsive linker. Upon NIR-II photoirradiation, APNA mediates photothermal effect, which not only triggers tumor ablation and immunogenic cell death but also initiates the cleavage of thermolabile linker to liberate caged agonist for in-situ immune activation in deep solid tumor (8 mm). Such controlled immune regulation potentiates systemic antitumor immunity, leading to promoted cytotoxic T lymphocytes and helper T cell infiltration in distal tumor, lung and liver to inhibit cancer metastasis. Thereby, the present work illustrates a generic strategy to prepare pro-immunostimulants for spatiotemporal regulation of cancer nano-immunotherapy.
format Online
Article
Text
id pubmed-7854754
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-78547542021-02-11 Activatable polymer nanoagonist for second near-infrared photothermal immunotherapy of cancer Jiang, Yuyan Huang, Jiaguo Xu, Cheng Pu, Kanyi Nat Commun Article Nanomedicine in combination with immunotherapy offers opportunities to treat cancer in a safe and effective manner; however, remote control of immune response with spatiotemporal precision remains challenging. We herein report a photothermally activatable polymeric pro-nanoagonist (APNA) that is specifically regulated by deep-tissue-penetrating second near-infrared (NIR-II) light for combinational photothermal immunotherapy. APNA is constructed from covalent conjugation of an immunostimulant onto a NIR-II semiconducting transducer through a labile thermo-responsive linker. Upon NIR-II photoirradiation, APNA mediates photothermal effect, which not only triggers tumor ablation and immunogenic cell death but also initiates the cleavage of thermolabile linker to liberate caged agonist for in-situ immune activation in deep solid tumor (8 mm). Such controlled immune regulation potentiates systemic antitumor immunity, leading to promoted cytotoxic T lymphocytes and helper T cell infiltration in distal tumor, lung and liver to inhibit cancer metastasis. Thereby, the present work illustrates a generic strategy to prepare pro-immunostimulants for spatiotemporal regulation of cancer nano-immunotherapy. Nature Publishing Group UK 2021-02-02 /pmc/articles/PMC7854754/ /pubmed/33531498 http://dx.doi.org/10.1038/s41467-021-21047-0 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Jiang, Yuyan
Huang, Jiaguo
Xu, Cheng
Pu, Kanyi
Activatable polymer nanoagonist for second near-infrared photothermal immunotherapy of cancer
title Activatable polymer nanoagonist for second near-infrared photothermal immunotherapy of cancer
title_full Activatable polymer nanoagonist for second near-infrared photothermal immunotherapy of cancer
title_fullStr Activatable polymer nanoagonist for second near-infrared photothermal immunotherapy of cancer
title_full_unstemmed Activatable polymer nanoagonist for second near-infrared photothermal immunotherapy of cancer
title_short Activatable polymer nanoagonist for second near-infrared photothermal immunotherapy of cancer
title_sort activatable polymer nanoagonist for second near-infrared photothermal immunotherapy of cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7854754/
https://www.ncbi.nlm.nih.gov/pubmed/33531498
http://dx.doi.org/10.1038/s41467-021-21047-0
work_keys_str_mv AT jiangyuyan activatablepolymernanoagonistforsecondnearinfraredphotothermalimmunotherapyofcancer
AT huangjiaguo activatablepolymernanoagonistforsecondnearinfraredphotothermalimmunotherapyofcancer
AT xucheng activatablepolymernanoagonistforsecondnearinfraredphotothermalimmunotherapyofcancer
AT pukanyi activatablepolymernanoagonistforsecondnearinfraredphotothermalimmunotherapyofcancer