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Association of urinary sodium and potassium excretion with systolic blood pressure in the Dietary Approaches to Stop Hypertension Sodium Trial
The 2019 National Academy of Science, Engineering and Medicine Dietary Reference Intakes (DRI) for Sodium (Na(+)) and Potassium (K(+)) Report concluded there remains insufficient evidence to establish a K(+) DRI. This study tested the hypothesis that reduced Na(+) and increased K(+) excretion will p...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7854834/ https://www.ncbi.nlm.nih.gov/pubmed/32661268 http://dx.doi.org/10.1038/s41371-020-0375-8 |
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author | Chaudhary, Parul Wainford, Richard D. |
author_facet | Chaudhary, Parul Wainford, Richard D. |
author_sort | Chaudhary, Parul |
collection | PubMed |
description | The 2019 National Academy of Science, Engineering and Medicine Dietary Reference Intakes (DRI) for Sodium (Na(+)) and Potassium (K(+)) Report concluded there remains insufficient evidence to establish a K(+) DRI. This study tested the hypothesis that reduced Na(+) and increased K(+) excretion will positively associate with lower blood pressure in salt sensitive (SS) and salt resistant (SR) participants in the Dietary Approaches to Stop Hypertension Sodium Trial (DASH–Sodium). Via the NHLBI BioLINCC we accessed the DASH-Sodium dataset for data on systolic blood pressure (SBP), 24-h urinary Na(+) and K(+) excretion at screening (regular patient diet; N = 186, SS N = 222 SR) and post DASH diet (N = 71 SS, N = 119 SR). The relationships between SBP, urinary Na(+) and K(+) excretion, and Na(+)/K(+) ratio were assessed via linear regression. At screening elevated urinary Na(+) excretion positively associated with SBP in SS (1 g increase in urinary Na(+) excretion = +1 0 ± 0.4 mmHg) but not SR participants, and urinary K(+) excretion of <1 g K(+)/day was associated with higher SBP in SS and SR participants. Urinary K(+) excretion ≥1 g/day, or a decreases in urinary Na(+)/K(+) ratio, was not associated with lower SBP. Post the DASH–sodium diet intervention, SBP was reduced in SS and SR participants. However, no correlation was observed between reduced SBP and urinary K(+) excretion or the urinary Na(+)/K(+) ratio irrespective of the salt sensitivity of blood pressure. Our data support the DRI recommendation not to establish a K(+) DRI and suggest further evidence is required to support a reduced Na(+)/K(+) ratio to lower SBP. |
format | Online Article Text |
id | pubmed-7854834 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-78548342021-07-16 Association of urinary sodium and potassium excretion with systolic blood pressure in the Dietary Approaches to Stop Hypertension Sodium Trial Chaudhary, Parul Wainford, Richard D. J Hum Hypertens Article The 2019 National Academy of Science, Engineering and Medicine Dietary Reference Intakes (DRI) for Sodium (Na(+)) and Potassium (K(+)) Report concluded there remains insufficient evidence to establish a K(+) DRI. This study tested the hypothesis that reduced Na(+) and increased K(+) excretion will positively associate with lower blood pressure in salt sensitive (SS) and salt resistant (SR) participants in the Dietary Approaches to Stop Hypertension Sodium Trial (DASH–Sodium). Via the NHLBI BioLINCC we accessed the DASH-Sodium dataset for data on systolic blood pressure (SBP), 24-h urinary Na(+) and K(+) excretion at screening (regular patient diet; N = 186, SS N = 222 SR) and post DASH diet (N = 71 SS, N = 119 SR). The relationships between SBP, urinary Na(+) and K(+) excretion, and Na(+)/K(+) ratio were assessed via linear regression. At screening elevated urinary Na(+) excretion positively associated with SBP in SS (1 g increase in urinary Na(+) excretion = +1 0 ± 0.4 mmHg) but not SR participants, and urinary K(+) excretion of <1 g K(+)/day was associated with higher SBP in SS and SR participants. Urinary K(+) excretion ≥1 g/day, or a decreases in urinary Na(+)/K(+) ratio, was not associated with lower SBP. Post the DASH–sodium diet intervention, SBP was reduced in SS and SR participants. However, no correlation was observed between reduced SBP and urinary K(+) excretion or the urinary Na(+)/K(+) ratio irrespective of the salt sensitivity of blood pressure. Our data support the DRI recommendation not to establish a K(+) DRI and suggest further evidence is required to support a reduced Na(+)/K(+) ratio to lower SBP. Nature Publishing Group UK 2020-07-13 2021 /pmc/articles/PMC7854834/ /pubmed/32661268 http://dx.doi.org/10.1038/s41371-020-0375-8 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Chaudhary, Parul Wainford, Richard D. Association of urinary sodium and potassium excretion with systolic blood pressure in the Dietary Approaches to Stop Hypertension Sodium Trial |
title | Association of urinary sodium and potassium excretion with systolic blood pressure in the Dietary Approaches to Stop Hypertension Sodium Trial |
title_full | Association of urinary sodium and potassium excretion with systolic blood pressure in the Dietary Approaches to Stop Hypertension Sodium Trial |
title_fullStr | Association of urinary sodium and potassium excretion with systolic blood pressure in the Dietary Approaches to Stop Hypertension Sodium Trial |
title_full_unstemmed | Association of urinary sodium and potassium excretion with systolic blood pressure in the Dietary Approaches to Stop Hypertension Sodium Trial |
title_short | Association of urinary sodium and potassium excretion with systolic blood pressure in the Dietary Approaches to Stop Hypertension Sodium Trial |
title_sort | association of urinary sodium and potassium excretion with systolic blood pressure in the dietary approaches to stop hypertension sodium trial |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7854834/ https://www.ncbi.nlm.nih.gov/pubmed/32661268 http://dx.doi.org/10.1038/s41371-020-0375-8 |
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