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Effect of Running Exercise on Oxidative Stress Biomarkers: A Systematic Review

Background: Exercise induced health benefits are limited by the overaccumulation of reactive oxygen species (ROS). ROS and further oxidative stress could potentially induce muscle damage which could result in poor exercise performance. However, predicting ROS induced oxidative stress in response to...

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Autores principales: Thirupathi, Anand, Pinho, Ricardo A., Ugbolue, Ukadike C., He, Yuhuan, Meng, Yao, Gu, Yaodong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7854914/
https://www.ncbi.nlm.nih.gov/pubmed/33551836
http://dx.doi.org/10.3389/fphys.2020.610112
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author Thirupathi, Anand
Pinho, Ricardo A.
Ugbolue, Ukadike C.
He, Yuhuan
Meng, Yao
Gu, Yaodong
author_facet Thirupathi, Anand
Pinho, Ricardo A.
Ugbolue, Ukadike C.
He, Yuhuan
Meng, Yao
Gu, Yaodong
author_sort Thirupathi, Anand
collection PubMed
description Background: Exercise induced health benefits are limited by the overaccumulation of reactive oxygen species (ROS). ROS and further oxidative stress could potentially induce muscle damage which could result in poor exercise performance. However, predicting ROS induced oxidative stress in response to endurance training has several limitations in terms of selecting biomarkers that are used to measure oxidative stress. Objective: The purpose of this study was to systematically investigate the suitable biomarkers that predict oxidative stress status among runners. Methods: According to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement, a search for relevant articles was carried out on PubMed/Medline, ISI Web of Science, and Google Scholar using related search terms such as oxidative damage, ROS, exercise, physical training, running, marathon, and ultramarathon. Results: Outcomes included (1) running programs like a half-marathon, ultramarathon, and iron-man race, (2) measuring biochemical assessment of oxidative damage markers such as malondialdehyde (MDA), protein carbonyl (PC), total antioxidant capacity (TAC), thiobarbituric acid reactive substances (TBARS), 8-Oxo-2'-deoxyguanosine (8-OH-dG), 4-hydroxynonenal (HNE), and F1-isoprostones, and enzymatic and non-enzymatic antioxidants level. Conclusions: This study concluded that a running exercise does not elicit a response to specific biomarkers of oxidative stress, instead, oxidative damage markers of lipids, proteins, and various enzymatic and non-enzymatic antioxidants are expressed according to the training status of the individual.
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spelling pubmed-78549142021-02-04 Effect of Running Exercise on Oxidative Stress Biomarkers: A Systematic Review Thirupathi, Anand Pinho, Ricardo A. Ugbolue, Ukadike C. He, Yuhuan Meng, Yao Gu, Yaodong Front Physiol Physiology Background: Exercise induced health benefits are limited by the overaccumulation of reactive oxygen species (ROS). ROS and further oxidative stress could potentially induce muscle damage which could result in poor exercise performance. However, predicting ROS induced oxidative stress in response to endurance training has several limitations in terms of selecting biomarkers that are used to measure oxidative stress. Objective: The purpose of this study was to systematically investigate the suitable biomarkers that predict oxidative stress status among runners. Methods: According to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement, a search for relevant articles was carried out on PubMed/Medline, ISI Web of Science, and Google Scholar using related search terms such as oxidative damage, ROS, exercise, physical training, running, marathon, and ultramarathon. Results: Outcomes included (1) running programs like a half-marathon, ultramarathon, and iron-man race, (2) measuring biochemical assessment of oxidative damage markers such as malondialdehyde (MDA), protein carbonyl (PC), total antioxidant capacity (TAC), thiobarbituric acid reactive substances (TBARS), 8-Oxo-2'-deoxyguanosine (8-OH-dG), 4-hydroxynonenal (HNE), and F1-isoprostones, and enzymatic and non-enzymatic antioxidants level. Conclusions: This study concluded that a running exercise does not elicit a response to specific biomarkers of oxidative stress, instead, oxidative damage markers of lipids, proteins, and various enzymatic and non-enzymatic antioxidants are expressed according to the training status of the individual. Frontiers Media S.A. 2021-01-20 /pmc/articles/PMC7854914/ /pubmed/33551836 http://dx.doi.org/10.3389/fphys.2020.610112 Text en Copyright © 2021 Thirupathi, Pinho, Ugbolue, He, Meng and Gu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Thirupathi, Anand
Pinho, Ricardo A.
Ugbolue, Ukadike C.
He, Yuhuan
Meng, Yao
Gu, Yaodong
Effect of Running Exercise on Oxidative Stress Biomarkers: A Systematic Review
title Effect of Running Exercise on Oxidative Stress Biomarkers: A Systematic Review
title_full Effect of Running Exercise on Oxidative Stress Biomarkers: A Systematic Review
title_fullStr Effect of Running Exercise on Oxidative Stress Biomarkers: A Systematic Review
title_full_unstemmed Effect of Running Exercise on Oxidative Stress Biomarkers: A Systematic Review
title_short Effect of Running Exercise on Oxidative Stress Biomarkers: A Systematic Review
title_sort effect of running exercise on oxidative stress biomarkers: a systematic review
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7854914/
https://www.ncbi.nlm.nih.gov/pubmed/33551836
http://dx.doi.org/10.3389/fphys.2020.610112
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