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Physiologically Based Pharmacokinetic Modeling of Central Nervous System Pharmacokinetics of CDK4/6 Inhibitors to Guide Selection of Drug and Dosing Regimen for Brain Cancer Treatment

A better understanding of the human central nervous system (CNS) pharmacokinetics is critical to the selection of the right drug and refinement of dosing regimen for more effective treatment of primary and metastatic brain cancer. Using the physiologically‐based pharmacokinetic (PBPK) modeling appro...

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Detalles Bibliográficos
Autores principales:	Li, Jing, Jiang, Jun, Wu, Jianmei, Bao, Xun, Sanai, Nader
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7854954/ https://www.ncbi.nlm.nih.gov/pubmed/32799335 http://dx.doi.org/10.1002/cpt.2021

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