Cryptic phosphorylation in nucleoside natural product biosynthesis

Kinases are annotated in many nucleoside biosynthetic gene clusters (BGCs) but generally are considered responsible only for self-resistance. Here, we report an unexpected 2’-phosphorylation of nucleoside biosynthetic intermediates in the nikkomycin and polyoxin pathways. This phosphorylation is a u...

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Detalles Bibliográficos
Autores principales: Draelos, Matthew M., Thanapipatsiri, Anyarat, Sucipto, Hilda, Yokoyama, Kenichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7855722/
https://www.ncbi.nlm.nih.gov/pubmed/33257873
http://dx.doi.org/10.1038/s41589-020-00656-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7855722/
https://www.ncbi.nlm.nih.gov/pubmed/33257873
http://dx.doi.org/10.1038/s41589-020-00656-8

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