Cargando…

Accumulation of neurofibrillary tangles and activated microglia is associated with lower neuron densities in the aphasic variant of Alzheimer’s disease

The neurofibrillary tangles (NFT) and amyloid‐ß plaques (AP) that comprise Alzheimer’s disease (AD) neuropathology are associated with neurodegeneration and microglial activation. Activated microglia exist on a dynamic spectrum of morphologic subtypes that include resting, surveillant microglia capa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ohm, Daniel T., Fought, Angela J., Martersteck, Adam, Coventry, Christina, Sridhar, Jaiashre, Gefen, Tamar, Weintraub, Sandra, Bigio, Eileen, Mesulam, M.‐Marsel, Rogalski, Emily, Geula, Changiz
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7855834/ https://www.ncbi.nlm.nih.gov/pubmed/33010092 http://dx.doi.org/10.1111/bpa.12902

Ejemplares similares

Focal amyloid and asymmetric tau in an imaging-to-autopsy case of clinical primary progressive aphasia with Alzheimer disease neuropathology
por: Martersteck, Adam, et al.
Publicado: (2022)

Activated Microglia in Cortical White Matter Across Cognitive Aging Trajectories
por: Gefen, Tamar, et al.
Publicado: (2019)

Proof of concept demonstration of optimal composite MRI endpoints for clinical trials
por: Edland, Steven D., et al.
Publicado: (2016)

Differential vulnerability of the dentate gyrus to tauopathies in dementias
por: Kawles, Allegra, et al.
Publicado: (2023)

Distinct and shared neuropsychiatric phenotypes in FTLD-tauopathies
por: Keszycki, Rachel, et al.
Publicado: (2023)

Genes associated with the progression of neurofibrillary tangles in Alzheimer's disease
por: Miyashita, A, et al.
Publicado: (2014)

The proteome of granulovacuolar degeneration and neurofibrillary tangles in Alzheimer’s disease
por: Hondius, David C., et al.
Publicado: (2021)

Aluminum and Tau in Neurofibrillary Tangles in Familial Alzheimer’s Disease
por: Mold, Matthew John, et al.
Publicado: (2021)

Propagation of TDP-43 proteinopathy in neurodegenerative disorders
por: Keszycki, Rachel, et al.
Publicado: (2021)

Associations of MAP2K3 Gene Variants With Superior Memory in SuperAgers
por: Huentelman, Matthew J., et al.
Publicado: (2018)

Expression of CD74 is increased in neurofibrillary tangles in Alzheimer's disease
por: Bryan, Kathryn J, et al.
Publicado: (2008)

Estrogen receptor-α is localized to neurofibrillary tangles in Alzheimer’s disease
por: Wang, Chunyu, et al.
Publicado: (2016)

In vivo quantification of neurofibrillary tangles with [(18)F]MK-6240
por: Pascoal, Tharick A., et al.
Publicado: (2018)

Alzheimer's polygenic hazard score in SuperAgers: SuperGenes or SuperResilience?
por: Spencer, Barbara E., et al.
Publicado: (2022)

Clinical Neuropathology image 5-2016: neurofibrillary tangle-rich ganglioglioma
por: Gelpi, Ellen, et al.
Publicado: (2016)

Braak neurofibrillary tangle staging prediction from in vivo MRI metrics
por: Dallaire-Théroux, Caroline, et al.
Publicado: (2019)

Association of Neighborhood-Level Disadvantage With Neurofibrillary Tangles on Neuropathological Tissue Assessment
por: Powell, W. Ryan, et al.
Publicado: (2022)

Fluent molecular mixing of Tau isoforms in Alzheimer’s disease neurofibrillary tangles
por: Dregni, Aurelio J., et al.
Publicado: (2022)

Anatomical evidence of an indirect pathway for word repetition
por: Forkel, Stephanie J., et al.
Publicado: (2020)

Apical dendrite degeneration, a novel cellular pathology for Betz cells in ALS
por: Genç, Barış, et al.
Publicado: (2017)

Re-examining tau-immunoreactive pathology in the population: granulovacuolar degeneration and neurofibrillary tangles
por: Hunter, Sally, et al.
Publicado: (2015)

Phosphatidylinositol-4,5-bisphosphate is enriched in granulovacuolar degeneration bodies and neurofibrillary tangles
por: Nishikawa, Tomokazu, et al.
Publicado: (2014)

Dietary exposure to an environmental toxin triggers neurofibrillary tangles and amyloid deposits in the brain
por: Cox, Paul Alan, et al.
Publicado: (2016)

Susceptibility to neurofibrillary tangles: role of the PTPRD locus and limited pleiotropy with other neuropathologies
por: Chibnik, Lori B, et al.
Publicado: (2017)

NDRG2 Expression Correlates with Neurofibrillary Tangles and Microglial Pathology in the Ageing Brain
por: Fadul, Motaz M., et al.
Publicado: (2020)

Entorhinal Subfield Vulnerability to Neurofibrillary Tangles in Aging and the Preclinical Stage of Alzheimer’s Disease
por: Llamas-Rodríguez, Josué, et al.
Publicado: (2022)

Artificial intelligence-derived neurofibrillary tangle burden is associated with antemortem cognitive impairment
por: Marx, Gabriel A., et al.
Publicado: (2022)

Inside Alzheimer brain with CLARITY: senile plaques, neurofibrillary tangles and axons in 3-D
por: Ando, Kunie, et al.
Publicado: (2014)

Highly Selective Tau-SPECT Imaging Probes for Detection of Neurofibrillary Tangles in Alzheimer’s Disease
por: Ono, Masahiro, et al.
Publicado: (2016)

Aluminum and Neurofibrillary Tangle Co-Localization in Familial Alzheimer’s Disease and Related Neurological Disorders
por: Mold, Matthew John, et al.
Publicado: (2020)

Subregional Density of Neurons, Neurofibrillary Tangles and Amyloid Plaques in the Hippocampus of Patients With Alzheimer’s Disease
por: Furcila, Diana, et al.
Publicado: (2019)

Visualization of neurofibrillary tangle maturity in Alzheimer's disease: A clinicopathologic perspective for biomarker research
por: Moloney, Christina M., et al.
Publicado: (2021)

Distinct Transcriptomic Responses to Aβ plaques, Neurofibrillary Tangles, and APOE in Alzheimer’s Disease
por: Das, Sudeshna, et al.
Publicado: (2023)

Neurofibrillary tangles in Alzheimer's disease: elucidation of the molecular mechanism by immunohistochemistry and tau protein phospho-proteomics
por: Metaxas, Athanasios, et al.
Publicado: (2016)

Altered Regulation of KIAA0566, and Katanin Signaling Expression in the Locus Coeruleus With Neurofibrillary Tangle Pathology
por: Andrés-Benito, Pol, et al.
Publicado: (2018)

Early amygdala and ERC atrophy linked to 3D reconstruction of rostral neurofibrillary tau tangle pathology in Alzheimer’s disease()
por: Stouffer, Kaitlin M., et al.
Publicado: (2023)

Vitamin E therapy prevents the accumulation of congophilic amyloid plaques and neurofibrillary tangles in the hippocampus in a rat model of Alzheimer’s disease
por: Jahanshahi, Mehrdad, et al.
Publicado: (2020)

Hyperspectral Raman imaging of neuritic plaques and neurofibrillary tangles in brain tissue from Alzheimer’s disease patients
por: Michael, Ralph, et al.
Publicado: (2017)

Use of Zebrafish Genetic Models to Study Etiology of the Amyloid-Beta and Neurofibrillary Tangle Pathways in Alzheimer's Disease
por: Kiper, Keturah, et al.
Publicado: (2022)

Mechanism involved in insulin resistance via accumulation of β-amyloid and neurofibrillary tangles: link between type 2 diabetes and Alzheimer’s disease
por: Rad, Sima Kianpour, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_it1de58hd3piv5c7pskaur4ptq