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Epidemiology and Burden of Human Papillomavirus and Related Diseases, Molecular Pathogenesis, and Vaccine Evaluation

Diagnosed in more than 90% of cervical cancers, the fourth deadliest cancer in women, human papillomavirus (HPV) is currently the most common pathogen responsible for female cancers. Moreover, HPV infection is associated with many other diseases, including cutaneous and anogenital warts, and genital...

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Autores principales: Kombe Kombe, Arnaud John, Li, Bofeng, Zahid, Ayesha, Mengist, Hylemariam Mihiretie, Bounda, Guy-Armel, Zhou, Ying, Jin, Tengchuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7855977/
https://www.ncbi.nlm.nih.gov/pubmed/33553082
http://dx.doi.org/10.3389/fpubh.2020.552028
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author Kombe Kombe, Arnaud John
Li, Bofeng
Zahid, Ayesha
Mengist, Hylemariam Mihiretie
Bounda, Guy-Armel
Zhou, Ying
Jin, Tengchuan
author_facet Kombe Kombe, Arnaud John
Li, Bofeng
Zahid, Ayesha
Mengist, Hylemariam Mihiretie
Bounda, Guy-Armel
Zhou, Ying
Jin, Tengchuan
author_sort Kombe Kombe, Arnaud John
collection PubMed
description Diagnosed in more than 90% of cervical cancers, the fourth deadliest cancer in women, human papillomavirus (HPV) is currently the most common pathogen responsible for female cancers. Moreover, HPV infection is associated with many other diseases, including cutaneous and anogenital warts, and genital and upper aerodigestive tract cancers. The incidence and prevalence of these pathologies vary considerably depending on factors including HPV genotype, regional conditions, the study population, and the anatomical site sampled. Recently, features of the cervicovaginal microbiota are found to be associated with the incidence of HPV-related diseases, presenting a novel approach to identify high-risk women through both blood and cervical samples. Overall, the HPV repartition data show that HPV infection and related diseases are more prevalent in developing countries. Moreover, the available (2-, 4-, and 9-valent) vaccines based on virus-like particles, despite their proven effectiveness and safety, present some limitations in terms of system development cost, transport cold chain, and oncogenic HPV variants. In addition, vaccination programs face some challenges, leading to a considerable burden of HPV infection and related diseases. Therefore, even though the new (9-valent) vaccine seems promising, next-generation vaccines as well as awareness programs associated with HPV vaccination and budget reinforcements for immunization are needed.
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spelling pubmed-78559772021-02-04 Epidemiology and Burden of Human Papillomavirus and Related Diseases, Molecular Pathogenesis, and Vaccine Evaluation Kombe Kombe, Arnaud John Li, Bofeng Zahid, Ayesha Mengist, Hylemariam Mihiretie Bounda, Guy-Armel Zhou, Ying Jin, Tengchuan Front Public Health Public Health Diagnosed in more than 90% of cervical cancers, the fourth deadliest cancer in women, human papillomavirus (HPV) is currently the most common pathogen responsible for female cancers. Moreover, HPV infection is associated with many other diseases, including cutaneous and anogenital warts, and genital and upper aerodigestive tract cancers. The incidence and prevalence of these pathologies vary considerably depending on factors including HPV genotype, regional conditions, the study population, and the anatomical site sampled. Recently, features of the cervicovaginal microbiota are found to be associated with the incidence of HPV-related diseases, presenting a novel approach to identify high-risk women through both blood and cervical samples. Overall, the HPV repartition data show that HPV infection and related diseases are more prevalent in developing countries. Moreover, the available (2-, 4-, and 9-valent) vaccines based on virus-like particles, despite their proven effectiveness and safety, present some limitations in terms of system development cost, transport cold chain, and oncogenic HPV variants. In addition, vaccination programs face some challenges, leading to a considerable burden of HPV infection and related diseases. Therefore, even though the new (9-valent) vaccine seems promising, next-generation vaccines as well as awareness programs associated with HPV vaccination and budget reinforcements for immunization are needed. Frontiers Media S.A. 2021-01-20 /pmc/articles/PMC7855977/ /pubmed/33553082 http://dx.doi.org/10.3389/fpubh.2020.552028 Text en Copyright © 2021 Kombe Kombe, Li, Zahid, Mengist, Bounda, Zhou and Jin. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Public Health
Kombe Kombe, Arnaud John
Li, Bofeng
Zahid, Ayesha
Mengist, Hylemariam Mihiretie
Bounda, Guy-Armel
Zhou, Ying
Jin, Tengchuan
Epidemiology and Burden of Human Papillomavirus and Related Diseases, Molecular Pathogenesis, and Vaccine Evaluation
title Epidemiology and Burden of Human Papillomavirus and Related Diseases, Molecular Pathogenesis, and Vaccine Evaluation
title_full Epidemiology and Burden of Human Papillomavirus and Related Diseases, Molecular Pathogenesis, and Vaccine Evaluation
title_fullStr Epidemiology and Burden of Human Papillomavirus and Related Diseases, Molecular Pathogenesis, and Vaccine Evaluation
title_full_unstemmed Epidemiology and Burden of Human Papillomavirus and Related Diseases, Molecular Pathogenesis, and Vaccine Evaluation
title_short Epidemiology and Burden of Human Papillomavirus and Related Diseases, Molecular Pathogenesis, and Vaccine Evaluation
title_sort epidemiology and burden of human papillomavirus and related diseases, molecular pathogenesis, and vaccine evaluation
topic Public Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7855977/
https://www.ncbi.nlm.nih.gov/pubmed/33553082
http://dx.doi.org/10.3389/fpubh.2020.552028
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