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The translational repressor 4E-BP1regulates RRM2 levels and functions as a tumor suppressor in Ewing Sarcoma Tumors

Ribonucleotide reductase (RNR), which is a heterodimeric tetramer composed of RRM1 and RRM2 subunits, is the rate-limiting enzyme in the synthesis of deoxyribonucleoside triphosphates (dNTPs) and essential for both DNA replication and the repair of DNA damage. The activity of RNR is coordinated with...

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Detalles Bibliográficos
Autores principales:	Goss, Kelli L., Koppenhafer, Stacia L., Waters, Torin, Terry, William W., Wen, Kuo-Kuang, Wu, Meng, Ostergaard, Jason, Gordon, Peter M., Gordon, David J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7856031/ https://www.ncbi.nlm.nih.gov/pubmed/33191406 http://dx.doi.org/10.1038/s41388-020-01552-0

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