Cargando…

Comparative proteomics identifies Schlafen 5 (SLFN5) as a herpes simplex virus restriction factor that suppresses viral transcription

Intrinsic antiviral host factors confer cellular defense by limiting virus replication and are often counteracted by viral countermeasures. We reasoned that host factors that inhibit viral gene expression could be identified by determining proteins bound to viral DNA (vDNA) in the absence of key vir...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Eui Tae, Dybas, Joseph M., Kulej, Katarzyna, Reyes, Emigdio D., Price, Alexander M., Akhtar, Lisa N., Orr, Ann, Garcia, Benjamin A., Boutell, Chris, Weitzman, Matthew D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7856100/
https://www.ncbi.nlm.nih.gov/pubmed/33432153
http://dx.doi.org/10.1038/s41564-020-00826-3