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Cytokine Storm in Coronavirus Disease 2019 and Adult-Onset Still’s Disease: Similarities and Differences

The catastrophic outbreak of coronavirus disease 2019 (COVID-19) is currently a public emergency. Adult-onset Still’s disease (AOSD) is an autoinflammatory disease characterized by life-threatening complications. Systemic hyperinflammation and cytokine storm play a critical role in the pathogenesis...

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Autores principales: Meng, Jianfen, Ma, Yuning, Jia, Jinchao, Wang, Mengyan, Teng, Jialin, Shi, Hui, Liu, Honglei, Su, Yutong, Ye, Junna, Sun, Yue, Cheng, Xiaobing, Chi, Huihui, Liu, Tingting, Zhu, Dehao, Zhou, Zhuochao, Wan, Liyan, Wang, Zhihong, Wang, Fan, Qiao, Xin, Chen, Xia, Zhang, Hao, Tang, Zihan, Yang, Chengde, Hu, Qiongyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7856388/
https://www.ncbi.nlm.nih.gov/pubmed/33552062
http://dx.doi.org/10.3389/fimmu.2020.603389
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author Meng, Jianfen
Ma, Yuning
Jia, Jinchao
Wang, Mengyan
Teng, Jialin
Shi, Hui
Liu, Honglei
Su, Yutong
Ye, Junna
Sun, Yue
Cheng, Xiaobing
Chi, Huihui
Liu, Tingting
Zhu, Dehao
Zhou, Zhuochao
Wan, Liyan
Wang, Zhihong
Wang, Fan
Qiao, Xin
Chen, Xia
Zhang, Hao
Tang, Zihan
Yang, Chengde
Hu, Qiongyi
author_facet Meng, Jianfen
Ma, Yuning
Jia, Jinchao
Wang, Mengyan
Teng, Jialin
Shi, Hui
Liu, Honglei
Su, Yutong
Ye, Junna
Sun, Yue
Cheng, Xiaobing
Chi, Huihui
Liu, Tingting
Zhu, Dehao
Zhou, Zhuochao
Wan, Liyan
Wang, Zhihong
Wang, Fan
Qiao, Xin
Chen, Xia
Zhang, Hao
Tang, Zihan
Yang, Chengde
Hu, Qiongyi
author_sort Meng, Jianfen
collection PubMed
description The catastrophic outbreak of coronavirus disease 2019 (COVID-19) is currently a public emergency. Adult-onset Still’s disease (AOSD) is an autoinflammatory disease characterized by life-threatening complications. Systemic hyperinflammation and cytokine storm play a critical role in the pathogenesis of both COVID-19 and AOSD. We aimed to compare the similarities and differences focusing on ferritin and cytokine levels between severe COVID-19 and active AOSD. A literature search was performed using the databases PubMed, EMBASE, and Web of Science to collect the levels of cytokine including IL-1β, IL-6, IL-18, TNF-α, IL-10, and ferritin in severe COVID-19 patients. After extracting available data of indicators of interest, we acquired these statistics with a single-arm meta-analysis. Furthermore, a comparison was conducted between 52 patients with active AOSD in our center and severe COVID-19 patients from databases. The levels of IL-6 and IL-10 were higher in severe COVID-19 compared with those in active AOSD. There were no significant differences on the cytokine of IL-1β and TNF-α. Fold changes of IL-18 were defined as the mean expression level ratio of severe COVID-19 to healthy controls in the COVID-19 study and active AOSD to healthy controls in our study, individually. Although the fold change of IL-18 in patients with AOSD was significantly higher than patients with severe COVID-19 (fold change: 594.00 vs 2.17), there was no statistical comparability. In addition, the level of ferritin was higher in active AOSD in comparison with severe COVID-19. Our findings suggest that severe COVID-19 and active AOSD have differences in cytokine panel and ferritin level, indicating the pathogenic role of ferritin in overwhelming inflammation. And it paves the way to make efficacy therapeutic strategy targeting the hyperinflammatory process in COVID-19 according to AOSD management, especially in severe COVID-19.
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spelling pubmed-78563882021-02-04 Cytokine Storm in Coronavirus Disease 2019 and Adult-Onset Still’s Disease: Similarities and Differences Meng, Jianfen Ma, Yuning Jia, Jinchao Wang, Mengyan Teng, Jialin Shi, Hui Liu, Honglei Su, Yutong Ye, Junna Sun, Yue Cheng, Xiaobing Chi, Huihui Liu, Tingting Zhu, Dehao Zhou, Zhuochao Wan, Liyan Wang, Zhihong Wang, Fan Qiao, Xin Chen, Xia Zhang, Hao Tang, Zihan Yang, Chengde Hu, Qiongyi Front Immunol Immunology The catastrophic outbreak of coronavirus disease 2019 (COVID-19) is currently a public emergency. Adult-onset Still’s disease (AOSD) is an autoinflammatory disease characterized by life-threatening complications. Systemic hyperinflammation and cytokine storm play a critical role in the pathogenesis of both COVID-19 and AOSD. We aimed to compare the similarities and differences focusing on ferritin and cytokine levels between severe COVID-19 and active AOSD. A literature search was performed using the databases PubMed, EMBASE, and Web of Science to collect the levels of cytokine including IL-1β, IL-6, IL-18, TNF-α, IL-10, and ferritin in severe COVID-19 patients. After extracting available data of indicators of interest, we acquired these statistics with a single-arm meta-analysis. Furthermore, a comparison was conducted between 52 patients with active AOSD in our center and severe COVID-19 patients from databases. The levels of IL-6 and IL-10 were higher in severe COVID-19 compared with those in active AOSD. There were no significant differences on the cytokine of IL-1β and TNF-α. Fold changes of IL-18 were defined as the mean expression level ratio of severe COVID-19 to healthy controls in the COVID-19 study and active AOSD to healthy controls in our study, individually. Although the fold change of IL-18 in patients with AOSD was significantly higher than patients with severe COVID-19 (fold change: 594.00 vs 2.17), there was no statistical comparability. In addition, the level of ferritin was higher in active AOSD in comparison with severe COVID-19. Our findings suggest that severe COVID-19 and active AOSD have differences in cytokine panel and ferritin level, indicating the pathogenic role of ferritin in overwhelming inflammation. And it paves the way to make efficacy therapeutic strategy targeting the hyperinflammatory process in COVID-19 according to AOSD management, especially in severe COVID-19. Frontiers Media S.A. 2021-01-19 /pmc/articles/PMC7856388/ /pubmed/33552062 http://dx.doi.org/10.3389/fimmu.2020.603389 Text en Copyright © 2021 Meng, Ma, Jia, Wang, Teng, Shi, Liu, Su, Ye, Sun, Cheng, Chi, Liu, Zhu, Zhou, Wan, Wang, Wang, Qiao, Chen, Zhang, Tang, Yang and Hu http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Meng, Jianfen
Ma, Yuning
Jia, Jinchao
Wang, Mengyan
Teng, Jialin
Shi, Hui
Liu, Honglei
Su, Yutong
Ye, Junna
Sun, Yue
Cheng, Xiaobing
Chi, Huihui
Liu, Tingting
Zhu, Dehao
Zhou, Zhuochao
Wan, Liyan
Wang, Zhihong
Wang, Fan
Qiao, Xin
Chen, Xia
Zhang, Hao
Tang, Zihan
Yang, Chengde
Hu, Qiongyi
Cytokine Storm in Coronavirus Disease 2019 and Adult-Onset Still’s Disease: Similarities and Differences
title Cytokine Storm in Coronavirus Disease 2019 and Adult-Onset Still’s Disease: Similarities and Differences
title_full Cytokine Storm in Coronavirus Disease 2019 and Adult-Onset Still’s Disease: Similarities and Differences
title_fullStr Cytokine Storm in Coronavirus Disease 2019 and Adult-Onset Still’s Disease: Similarities and Differences
title_full_unstemmed Cytokine Storm in Coronavirus Disease 2019 and Adult-Onset Still’s Disease: Similarities and Differences
title_short Cytokine Storm in Coronavirus Disease 2019 and Adult-Onset Still’s Disease: Similarities and Differences
title_sort cytokine storm in coronavirus disease 2019 and adult-onset still’s disease: similarities and differences
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7856388/
https://www.ncbi.nlm.nih.gov/pubmed/33552062
http://dx.doi.org/10.3389/fimmu.2020.603389
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