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Cytoplasmic Chaperones Enhance Soluble Expression of Anti-EGFR huscFv in Escherichia coli

BACKGROUND: Overexpression of EGFR is associated with carcinogenesis in more than 70% of head and neck cancers. Anti-EGFR monoclonal antibodies bind to the extracellular domain of EGFR and block the EGFR downstream signaling pathway, which results in the suppression of the growth of the tumor cells....

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Detalles Bibliográficos
Autores principales: Nazari, Atefeh, Farajnia, Safar, Zahri, Seber, Bagherlou, Nazanin, Tanoumand, Asghar, Rahbarnia, Leila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Institute of Genetic Engineering and Biotechnology 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7856399/
https://www.ncbi.nlm.nih.gov/pubmed/33542937
http://dx.doi.org/10.30498/IJB.2020.138200.2314