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Extracellular vesicles as mediators and markers of acute organ injury: current concepts
Due to the continued high incidence and mortality rate worldwide, there is a need to develop new strategies for the quick, precise, and valuable recognition of presenting injury pattern in traumatized and poly-traumatized patients. Extracellular vesicles (EVs) have been shown to facilitate intercell...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7856451/ https://www.ncbi.nlm.nih.gov/pubmed/33533957 http://dx.doi.org/10.1007/s00068-021-01607-1 |
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author | Weber, Birte Franz, Niklas Marzi, Ingo Henrich, Dirk Leppik, Liudmila |
author_facet | Weber, Birte Franz, Niklas Marzi, Ingo Henrich, Dirk Leppik, Liudmila |
author_sort | Weber, Birte |
collection | PubMed |
description | Due to the continued high incidence and mortality rate worldwide, there is a need to develop new strategies for the quick, precise, and valuable recognition of presenting injury pattern in traumatized and poly-traumatized patients. Extracellular vesicles (EVs) have been shown to facilitate intercellular communication processes between cells in close proximity as well as distant cells in healthy and disease organisms. miRNAs and proteins transferred by EVs play biological roles in maintaining normal organ structure and function under physiological conditions. In pathological conditions, EVs change the miRNAs and protein cargo composition, mediating or suppressing the injury consequences. Therefore, incorporating EVs with their unique protein and miRNAs signature into the list of promising new biomarkers is a logical next step. In this review, we discuss the general characteristics and technical aspects of EVs isolation and characterization. We discuss results of recent in vitro, in vivo, and patients study describing the role of EVs in different inflammatory diseases and traumatic organ injuries. miRNAs and protein signature of EVs found in patients with acute organ injury are also debated. |
format | Online Article Text |
id | pubmed-7856451 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-78564512021-02-03 Extracellular vesicles as mediators and markers of acute organ injury: current concepts Weber, Birte Franz, Niklas Marzi, Ingo Henrich, Dirk Leppik, Liudmila Eur J Trauma Emerg Surg Review Article Due to the continued high incidence and mortality rate worldwide, there is a need to develop new strategies for the quick, precise, and valuable recognition of presenting injury pattern in traumatized and poly-traumatized patients. Extracellular vesicles (EVs) have been shown to facilitate intercellular communication processes between cells in close proximity as well as distant cells in healthy and disease organisms. miRNAs and proteins transferred by EVs play biological roles in maintaining normal organ structure and function under physiological conditions. In pathological conditions, EVs change the miRNAs and protein cargo composition, mediating or suppressing the injury consequences. Therefore, incorporating EVs with their unique protein and miRNAs signature into the list of promising new biomarkers is a logical next step. In this review, we discuss the general characteristics and technical aspects of EVs isolation and characterization. We discuss results of recent in vitro, in vivo, and patients study describing the role of EVs in different inflammatory diseases and traumatic organ injuries. miRNAs and protein signature of EVs found in patients with acute organ injury are also debated. Springer Berlin Heidelberg 2021-02-03 2022 /pmc/articles/PMC7856451/ /pubmed/33533957 http://dx.doi.org/10.1007/s00068-021-01607-1 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Article Weber, Birte Franz, Niklas Marzi, Ingo Henrich, Dirk Leppik, Liudmila Extracellular vesicles as mediators and markers of acute organ injury: current concepts |
title | Extracellular vesicles as mediators and markers of acute organ injury: current concepts |
title_full | Extracellular vesicles as mediators and markers of acute organ injury: current concepts |
title_fullStr | Extracellular vesicles as mediators and markers of acute organ injury: current concepts |
title_full_unstemmed | Extracellular vesicles as mediators and markers of acute organ injury: current concepts |
title_short | Extracellular vesicles as mediators and markers of acute organ injury: current concepts |
title_sort | extracellular vesicles as mediators and markers of acute organ injury: current concepts |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7856451/ https://www.ncbi.nlm.nih.gov/pubmed/33533957 http://dx.doi.org/10.1007/s00068-021-01607-1 |
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