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Impact of liver-specific GLUT8 silencing on fructose-induced inflammation and omega oxidation
Excessive consumption of high-fructose diets is associated with insulin resistance, obesity, and non-alcoholic fatty liver disease (NAFLD). However, fructose differentially affects hepatic regulation of lipogenesis in males and females. Hence, additional studies are necessary in order to find strate...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7856473/ https://www.ncbi.nlm.nih.gov/pubmed/33554072 http://dx.doi.org/10.1016/j.isci.2021.102071 |
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author | Novelle, Marta G. Bravo, Susana Belén Deshons, Maxime Iglesias, Cristina García-Vence, María Annells, Rebecca da Silva Lima, Natália Nogueiras, Rubén Fernández-Rojo, Manuel Alejandro Diéguez, Carlos Romero-Picó, Amparo |
author_facet | Novelle, Marta G. Bravo, Susana Belén Deshons, Maxime Iglesias, Cristina García-Vence, María Annells, Rebecca da Silva Lima, Natália Nogueiras, Rubén Fernández-Rojo, Manuel Alejandro Diéguez, Carlos Romero-Picó, Amparo |
author_sort | Novelle, Marta G. |
collection | PubMed |
description | Excessive consumption of high-fructose diets is associated with insulin resistance, obesity, and non-alcoholic fatty liver disease (NAFLD). However, fructose differentially affects hepatic regulation of lipogenesis in males and females. Hence, additional studies are necessary in order to find strategies taking gender disparities in fructose-induced liver damage into consideration. Although the eighth member of facilitated glucose transporters (GLUT8) has been linked to fructose-induced macrosteatosis in female mice, its contribution to the inflammatory state of NAFLD remains to be elucidated. Combining pharmacological, biochemical, and proteomic approaches, we evaluated the preventive effect of targeted liver GLUT8 silencing on liver injury in a mice female fructose-induced non-alcoholic steatohepatitis female mouse model. Liver GLUT8-knockdown attenuated fructose-induced ER stress, recovered liver inflammation, and dramatically reduced fatty acid content, in part, via the omega oxidation. Therefore, this study links GLUT8 with liver inflammatory response and suggests GLUT8 as a potential target for the prevention of NAFLD. |
format | Online Article Text |
id | pubmed-7856473 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-78564732021-02-05 Impact of liver-specific GLUT8 silencing on fructose-induced inflammation and omega oxidation Novelle, Marta G. Bravo, Susana Belén Deshons, Maxime Iglesias, Cristina García-Vence, María Annells, Rebecca da Silva Lima, Natália Nogueiras, Rubén Fernández-Rojo, Manuel Alejandro Diéguez, Carlos Romero-Picó, Amparo iScience Article Excessive consumption of high-fructose diets is associated with insulin resistance, obesity, and non-alcoholic fatty liver disease (NAFLD). However, fructose differentially affects hepatic regulation of lipogenesis in males and females. Hence, additional studies are necessary in order to find strategies taking gender disparities in fructose-induced liver damage into consideration. Although the eighth member of facilitated glucose transporters (GLUT8) has been linked to fructose-induced macrosteatosis in female mice, its contribution to the inflammatory state of NAFLD remains to be elucidated. Combining pharmacological, biochemical, and proteomic approaches, we evaluated the preventive effect of targeted liver GLUT8 silencing on liver injury in a mice female fructose-induced non-alcoholic steatohepatitis female mouse model. Liver GLUT8-knockdown attenuated fructose-induced ER stress, recovered liver inflammation, and dramatically reduced fatty acid content, in part, via the omega oxidation. Therefore, this study links GLUT8 with liver inflammatory response and suggests GLUT8 as a potential target for the prevention of NAFLD. Elsevier 2021-01-19 /pmc/articles/PMC7856473/ /pubmed/33554072 http://dx.doi.org/10.1016/j.isci.2021.102071 Text en © 2021 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Novelle, Marta G. Bravo, Susana Belén Deshons, Maxime Iglesias, Cristina García-Vence, María Annells, Rebecca da Silva Lima, Natália Nogueiras, Rubén Fernández-Rojo, Manuel Alejandro Diéguez, Carlos Romero-Picó, Amparo Impact of liver-specific GLUT8 silencing on fructose-induced inflammation and omega oxidation |
title | Impact of liver-specific GLUT8 silencing on fructose-induced inflammation and omega oxidation |
title_full | Impact of liver-specific GLUT8 silencing on fructose-induced inflammation and omega oxidation |
title_fullStr | Impact of liver-specific GLUT8 silencing on fructose-induced inflammation and omega oxidation |
title_full_unstemmed | Impact of liver-specific GLUT8 silencing on fructose-induced inflammation and omega oxidation |
title_short | Impact of liver-specific GLUT8 silencing on fructose-induced inflammation and omega oxidation |
title_sort | impact of liver-specific glut8 silencing on fructose-induced inflammation and omega oxidation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7856473/ https://www.ncbi.nlm.nih.gov/pubmed/33554072 http://dx.doi.org/10.1016/j.isci.2021.102071 |
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