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Cuprizone markedly decreases kynurenic acid levels in the rodent brain tissue and plasma

BACKGROUND: The kynurenine (KYN) pathway (KP) of the tryptophan (TRP) metabolism seems to play a role in the pathomechanism of multiple sclerosis (MS). Cuprizone (CPZ) treated animals develop both demyelination (DEM) and remyelination (REM) in lack of peripheral immune response, such as the lesion p...

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Detalles Bibliográficos
Autores principales:	Polyák, Helga, Cseh, Edina Katalin, Bohár, Zsuzsanna, Rajda, Cecilia, Zádori, Dénes, Klivényi, Péter, Toldi, József, Vécsei, László
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7856478/ https://www.ncbi.nlm.nih.gov/pubmed/33553777 http://dx.doi.org/10.1016/j.heliyon.2021.e06124

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