Physical exercise may exert its therapeutic influence on Alzheimer's disease through the reversal of mitochondrial dysfunction via SIRT1–FOXO1/3–PINK1–Parkin-mediated mitophagy

• Physical exercise efficiently prevents the progression of Alzheimer's disease and mitigates the risk of developing the disease. • Physical exercise acts against the development and progression of Alzheimer's disease via promoting mitochondrial fitness. • Physical exercise may exert its t...

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Detalles Bibliográficos
Autores principales: Zhao, Na, Xia, Jie, Xu, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shanghai University of Sport 2021
Materias:
Opinion
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7856556/
https://www.ncbi.nlm.nih.gov/pubmed/32861777
http://dx.doi.org/10.1016/j.jshs.2020.08.009
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author Zhao, Na
Xia, Jie
Xu, Bo
author_facet Zhao, Na
Xia, Jie
Xu, Bo
author_sort Zhao, Na
collection PubMed
description • Physical exercise efficiently prevents the progression of Alzheimer's disease and mitigates the risk of developing the disease. • Physical exercise acts against the development and progression of Alzheimer's disease via promoting mitochondrial fitness. • Physical exercise may exert its therapeutic influence on Alzheimer's disease through the reversal of mitochondrial dysfunction via SIRT1-FOXO1/3-PINK1-Parkin–mediated mitophagy.
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spelling pubmed-78565562021-02-05 Physical exercise may exert its therapeutic influence on Alzheimer's disease through the reversal of mitochondrial dysfunction via SIRT1–FOXO1/3–PINK1–Parkin-mediated mitophagy Zhao, Na Xia, Jie Xu, Bo J Sport Health Sci Opinion • Physical exercise efficiently prevents the progression of Alzheimer's disease and mitigates the risk of developing the disease. • Physical exercise acts against the development and progression of Alzheimer's disease via promoting mitochondrial fitness. • Physical exercise may exert its therapeutic influence on Alzheimer's disease through the reversal of mitochondrial dysfunction via SIRT1-FOXO1/3-PINK1-Parkin–mediated mitophagy. Shanghai University of Sport 2021-01 2020-08-28 /pmc/articles/PMC7856556/ /pubmed/32861777 http://dx.doi.org/10.1016/j.jshs.2020.08.009 Text en © 2020 Published by Elsevier B.V. on behalf of Shanghai University of Sport. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Opinion
Zhao, Na
Xia, Jie
Xu, Bo
Physical exercise may exert its therapeutic influence on Alzheimer's disease through the reversal of mitochondrial dysfunction via SIRT1–FOXO1/3–PINK1–Parkin-mediated mitophagy
title Physical exercise may exert its therapeutic influence on Alzheimer's disease through the reversal of mitochondrial dysfunction via SIRT1–FOXO1/3–PINK1–Parkin-mediated mitophagy
title_full Physical exercise may exert its therapeutic influence on Alzheimer's disease through the reversal of mitochondrial dysfunction via SIRT1–FOXO1/3–PINK1–Parkin-mediated mitophagy
title_fullStr Physical exercise may exert its therapeutic influence on Alzheimer's disease through the reversal of mitochondrial dysfunction via SIRT1–FOXO1/3–PINK1–Parkin-mediated mitophagy
title_full_unstemmed Physical exercise may exert its therapeutic influence on Alzheimer's disease through the reversal of mitochondrial dysfunction via SIRT1–FOXO1/3–PINK1–Parkin-mediated mitophagy
title_short Physical exercise may exert its therapeutic influence on Alzheimer's disease through the reversal of mitochondrial dysfunction via SIRT1–FOXO1/3–PINK1–Parkin-mediated mitophagy
title_sort physical exercise may exert its therapeutic influence on alzheimer's disease through the reversal of mitochondrial dysfunction via sirt1–foxo1/3–pink1–parkin-mediated mitophagy
topic Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7856556/
https://www.ncbi.nlm.nih.gov/pubmed/32861777
http://dx.doi.org/10.1016/j.jshs.2020.08.009
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