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MicroRNA let-7b downregulates AML1-ETO oncogene expression in t(8;21) AML by targeting its 3′UTR

BACKGROUND: Acute myeloid leukemia (AML) with the t(8;21)(q22;q22) chromosomal translocation is among the most common subtypes of AML and produces the AML1-ETO (RUNX1-ETO, RUNX1-RUNX1T1) oncogenic fusion gene. AML1-ETO functions as an aberrant transcription factor which plays a key role in blocking...

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Detalles Bibliográficos
Autores principales:	Johnson, Daniel T., Davis, Amanda G., Zhou, Jie-Hua, Ball, Edward D., Zhang, Dong-Er
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7856722/ https://www.ncbi.nlm.nih.gov/pubmed/33531067 http://dx.doi.org/10.1186/s40164-021-00204-7

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