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A feasibility study of combined epigenetic and vaccine therapy in advanced colorectal cancer with pharmacodynamic endpoint

Epigenetic therapies may modulate the tumor microenvironment. We evaluated the safety and optimal sequence of combination DNA methyltransferase inhibitor guadecitabine with a granulocyte macrophage-colony-stimulating-factor (GM-CSF) secreting colon cancer (CRC) vaccine (GVAX) using a primary endpoin...

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Detalles Bibliográficos
Autores principales:	Bever, Katherine M., Thomas, Dwayne L., Zhang, Jiajia, Diaz Rivera, Ernie A., Rosner, Gary L., Zhu, Qingfeng, Nauroth, Julie M., Christmas, Brian, Thompson, Elizabeth D., Anders, Robert A., Judkins, Carol, Liu, Meizheng, Jaffee, Elizabeth M., Ahuja, Nita, Zheng, Lei, Azad, Nilofer S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Short Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7856736/ https://www.ncbi.nlm.nih.gov/pubmed/33531075 http://dx.doi.org/10.1186/s13148-021-01014-8

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