Effect of Irisin on LIF and integrin αvβ3 in rats of implantation failure

OBJECTIVE: The aim of this study is to investigate the effect of irisin on leukemia inhibitory factor (LIF) and integrin αvβ3 in implantation failure uterus. METHODS: Early pregnant rats were randomly divided into normal group (N), mifepristone treated group (M), irisin group (I) and progestin group...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhou, Li, Li, Chenggang, Liu, Xiangshu, Zhang, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7856750/
https://www.ncbi.nlm.nih.gov/pubmed/33536035
http://dx.doi.org/10.1186/s12958-021-00700-9
_version_ 1783646306827239424
author Zhou, Li
Li, Chenggang
Liu, Xiangshu
Zhang, Tao
author_facet Zhou, Li
Li, Chenggang
Liu, Xiangshu
Zhang, Tao
author_sort Zhou, Li
collection PubMed
description OBJECTIVE: The aim of this study is to investigate the effect of irisin on leukemia inhibitory factor (LIF) and integrin αvβ3 in implantation failure uterus. METHODS: Early pregnant rats were randomly divided into normal group (N), mifepristone treated group (M), irisin group (I) and progestin group (P). The implantation failure model was established using mifepristone. Second, we evaluated the average number of embryos and detected the expression of LIF and integrin αvβ3 protein and mRNA in endometrium. RESULTS: Compared with group M, the average number of embryos was significantly higher in group N, P and I, the expression of LIF and integrin αvβ3 in endometrium was significantly higher in group N, P and I. CONCLUSION: Irisin could improve the poor receptive state of endometrium by promoting LIF and integrin αvβ3 secretion to improve blastocyst implantation in rats of implantation failure.
format Online
Article
Text
id pubmed-7856750
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-78567502021-02-04 Effect of Irisin on LIF and integrin αvβ3 in rats of implantation failure Zhou, Li Li, Chenggang Liu, Xiangshu Zhang, Tao Reprod Biol Endocrinol Research OBJECTIVE: The aim of this study is to investigate the effect of irisin on leukemia inhibitory factor (LIF) and integrin αvβ3 in implantation failure uterus. METHODS: Early pregnant rats were randomly divided into normal group (N), mifepristone treated group (M), irisin group (I) and progestin group (P). The implantation failure model was established using mifepristone. Second, we evaluated the average number of embryos and detected the expression of LIF and integrin αvβ3 protein and mRNA in endometrium. RESULTS: Compared with group M, the average number of embryos was significantly higher in group N, P and I, the expression of LIF and integrin αvβ3 in endometrium was significantly higher in group N, P and I. CONCLUSION: Irisin could improve the poor receptive state of endometrium by promoting LIF and integrin αvβ3 secretion to improve blastocyst implantation in rats of implantation failure. BioMed Central 2021-02-03 /pmc/articles/PMC7856750/ /pubmed/33536035 http://dx.doi.org/10.1186/s12958-021-00700-9 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Zhou, Li
Li, Chenggang
Liu, Xiangshu
Zhang, Tao
Effect of Irisin on LIF and integrin αvβ3 in rats of implantation failure
title Effect of Irisin on LIF and integrin αvβ3 in rats of implantation failure
title_full Effect of Irisin on LIF and integrin αvβ3 in rats of implantation failure
title_fullStr Effect of Irisin on LIF and integrin αvβ3 in rats of implantation failure
title_full_unstemmed Effect of Irisin on LIF and integrin αvβ3 in rats of implantation failure
title_short Effect of Irisin on LIF and integrin αvβ3 in rats of implantation failure
title_sort effect of irisin on lif and integrin αvβ3 in rats of implantation failure
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7856750/
https://www.ncbi.nlm.nih.gov/pubmed/33536035
http://dx.doi.org/10.1186/s12958-021-00700-9
work_keys_str_mv AT zhouli effectofirisinonlifandintegrinavb3inratsofimplantationfailure
AT lichenggang effectofirisinonlifandintegrinavb3inratsofimplantationfailure
AT liuxiangshu effectofirisinonlifandintegrinavb3inratsofimplantationfailure
AT zhangtao effectofirisinonlifandintegrinavb3inratsofimplantationfailure

Ejemplares similares