TGR5 activation attenuates neuroinflammation via Pellino3 inhibition of caspase-8/NLRP3 after middle cerebral artery occlusion in rats

BACKGROUND: Nucleotide-binding oligomerization domain-like receptor pyrin domain-containing protein 3 (NLRP3) plays an important role in mediating inflammatory responses during ischemic stroke. Bile acid receptor Takeda-G-protein-receptor-5 (TGR5) has been identified as an important component in reg...

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Detalles Bibliográficos
Autores principales: Liang, Hui, Matei, Nathanael, McBride, Devin W., Xu, Yang, Zhou, Zhenhua, Tang, Jiping, Luo, Benyan, Zhang, John H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7856773/
https://www.ncbi.nlm.nih.gov/pubmed/33531049
http://dx.doi.org/10.1186/s12974-021-02087-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7856773/
https://www.ncbi.nlm.nih.gov/pubmed/33531049
http://dx.doi.org/10.1186/s12974-021-02087-1

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