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TGR5 activation attenuates neuroinflammation via Pellino3 inhibition of caspase-8/NLRP3 after middle cerebral artery occlusion in rats

BACKGROUND: Nucleotide-binding oligomerization domain-like receptor pyrin domain-containing protein 3 (NLRP3) plays an important role in mediating inflammatory responses during ischemic stroke. Bile acid receptor Takeda-G-protein-receptor-5 (TGR5) has been identified as an important component in reg...

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Detalles Bibliográficos
Autores principales:	Liang, Hui, Matei, Nathanael, McBride, Devin W., Xu, Yang, Zhou, Zhenhua, Tang, Jiping, Luo, Benyan, Zhang, John H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7856773/ https://www.ncbi.nlm.nih.gov/pubmed/33531049 http://dx.doi.org/10.1186/s12974-021-02087-1

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