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Nitric Oxide‐Driven Nanomotor for Deep Tissue Penetration and Multidrug Resistance Reversal in Cancer Therapy
Poor permeation of therapeutic agents and multidrug resistance (MDR) in solid tumors are the two major challenges that lead to the failure of the current chemotherapy methods. Herein, a zero‐waste doxorubicin‐loaded heparin/folic acid/l‐arginine (HFLA‐DOX) nanomotor with motion ability and sustained...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7856908/ https://www.ncbi.nlm.nih.gov/pubmed/33552861 http://dx.doi.org/10.1002/advs.202002525 |
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author | Wan, Mi Mi Chen, Huan Da Wang, Zhong Liu, Zhi Yong Yu, Yue Qi Li, Lin Miao, Zhuo Yue Wang, Xing Wen Wang, Qi Mao, Chun Shen, Jian Wei, Jia |
author_facet | Wan, Mi Mi Chen, Huan Da Wang, Zhong Liu, Zhi Yong Yu, Yue Qi Li, Lin Miao, Zhuo Yue Wang, Xing Wen Wang, Qi Mao, Chun Shen, Jian Wei, Jia |
author_sort | Wan, Mi Mi |
collection | PubMed |
description | Poor permeation of therapeutic agents and multidrug resistance (MDR) in solid tumors are the two major challenges that lead to the failure of the current chemotherapy methods. Herein, a zero‐waste doxorubicin‐loaded heparin/folic acid/l‐arginine (HFLA‐DOX) nanomotor with motion ability and sustained release of nitric oxide (NO) to achieve deep drug penetration and effective reversal of MDR in cancer chemotherapy is designed. The targeted recognition, penetration of blood vessels, intercellular penetration, special intracellular distribution (escaping from lysosomes and accumulating in Golgi and nucleus), 3D multicellular tumor spheroids (3D MTSs) penetration, degradation of tumor extracellular matrix (ECM), and reversal of MDR based on the synergistic effects of the motion ability and sustained NO release performance of the NO‐driven nanomotors are investigated in detail. Correspondingly, a new chemotherapy mode called recognition‐penetration‐reversal‐elimination is proposed, whose effectiveness is verified by in vitro cellular experiments and in vivo animal tumor model, which can not only provide effective solutions to these challenges encountered in cancer chemotherapy, but also apply to other therapy methods for the special deep‐tissue penetration ability of a therapeutic agent. |
format | Online Article Text |
id | pubmed-7856908 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78569082021-02-05 Nitric Oxide‐Driven Nanomotor for Deep Tissue Penetration and Multidrug Resistance Reversal in Cancer Therapy Wan, Mi Mi Chen, Huan Da Wang, Zhong Liu, Zhi Yong Yu, Yue Qi Li, Lin Miao, Zhuo Yue Wang, Xing Wen Wang, Qi Mao, Chun Shen, Jian Wei, Jia Adv Sci (Weinh) Full Papers Poor permeation of therapeutic agents and multidrug resistance (MDR) in solid tumors are the two major challenges that lead to the failure of the current chemotherapy methods. Herein, a zero‐waste doxorubicin‐loaded heparin/folic acid/l‐arginine (HFLA‐DOX) nanomotor with motion ability and sustained release of nitric oxide (NO) to achieve deep drug penetration and effective reversal of MDR in cancer chemotherapy is designed. The targeted recognition, penetration of blood vessels, intercellular penetration, special intracellular distribution (escaping from lysosomes and accumulating in Golgi and nucleus), 3D multicellular tumor spheroids (3D MTSs) penetration, degradation of tumor extracellular matrix (ECM), and reversal of MDR based on the synergistic effects of the motion ability and sustained NO release performance of the NO‐driven nanomotors are investigated in detail. Correspondingly, a new chemotherapy mode called recognition‐penetration‐reversal‐elimination is proposed, whose effectiveness is verified by in vitro cellular experiments and in vivo animal tumor model, which can not only provide effective solutions to these challenges encountered in cancer chemotherapy, but also apply to other therapy methods for the special deep‐tissue penetration ability of a therapeutic agent. John Wiley and Sons Inc. 2020-12-18 /pmc/articles/PMC7856908/ /pubmed/33552861 http://dx.doi.org/10.1002/advs.202002525 Text en © 2020 The Authors. Advanced Science published by Wiley‐VCH GmbH This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Full Papers Wan, Mi Mi Chen, Huan Da Wang, Zhong Liu, Zhi Yong Yu, Yue Qi Li, Lin Miao, Zhuo Yue Wang, Xing Wen Wang, Qi Mao, Chun Shen, Jian Wei, Jia Nitric Oxide‐Driven Nanomotor for Deep Tissue Penetration and Multidrug Resistance Reversal in Cancer Therapy |
title | Nitric Oxide‐Driven Nanomotor for Deep Tissue Penetration and Multidrug Resistance Reversal in Cancer Therapy |
title_full | Nitric Oxide‐Driven Nanomotor for Deep Tissue Penetration and Multidrug Resistance Reversal in Cancer Therapy |
title_fullStr | Nitric Oxide‐Driven Nanomotor for Deep Tissue Penetration and Multidrug Resistance Reversal in Cancer Therapy |
title_full_unstemmed | Nitric Oxide‐Driven Nanomotor for Deep Tissue Penetration and Multidrug Resistance Reversal in Cancer Therapy |
title_short | Nitric Oxide‐Driven Nanomotor for Deep Tissue Penetration and Multidrug Resistance Reversal in Cancer Therapy |
title_sort | nitric oxide‐driven nanomotor for deep tissue penetration and multidrug resistance reversal in cancer therapy |
topic | Full Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7856908/ https://www.ncbi.nlm.nih.gov/pubmed/33552861 http://dx.doi.org/10.1002/advs.202002525 |
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