Requirement of Bccip for the Regeneration of Intestinal Progenitors

BCCIP was originally identified as a BRCA2 and CDKN1A/p21 interaction protein. Although a partial loss of BCCIP function is sufficient to trigger genomic instability and tumorigenesis, complete deletion of BCCIP is lethal to cells. Using Rosa26-CreERT2 mouse models, we found that induced Bccip delet...

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Detalles Bibliográficos
Autores principales: Lu, Huimei, Ye, Caiyong, Liu, Jingmei, Rabson, Arnold B., Verzi, Michael, De, Subhajyoti, Shen, Zhiyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Investigative Pathology 2021
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7857062/
https://www.ncbi.nlm.nih.gov/pubmed/33039352
http://dx.doi.org/10.1016/j.ajpath.2020.09.009

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