A Highly Reproducible Micro U‐Well Array Plate Facilitating High‐Throughput Tumor Spheroid Culture and Drug Assessment (Global Challenges 2/2021)

In article number 2000056 Ting‐Yuan Tu and co‐workers demonstrate a facile and highly reproducible laser‐ablated micro U‐well with optimal array arrangement. Cell‐loss free formation of multicellular tumor spheroids is performed in 96‐well plates for high‐throughput drug screening of cisplatin. Dose...

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Detalles Bibliográficos
Autores principales: Wu, Kuang‐Wei, Kuo, Ching‐Te, Tu, Ting‐Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7857124/
http://dx.doi.org/10.1002/gch2.202170021
Descripción
Sumario:In article number 2000056 Ting‐Yuan Tu and co‐workers demonstrate a facile and highly reproducible laser‐ablated micro U‐well with optimal array arrangement. Cell‐loss free formation of multicellular tumor spheroids is performed in 96‐well plates for high‐throughput drug screening of cisplatin. Dose‐response assays are investigated on T24, A549, and Huh‐7 in both 2D and multicellular tumor spheroid (MCTS) conditions. The permeability dynamics of each type of MCTS are examined. [Image: see text]

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