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A red herring, a wild-goose chase, and an unexpected diagnosis of concomitant malignancy and sarcoidosis

A 49-year-old male was evaluated in our hospital for chronic cough, cervical lymphadenopathy, and a testicular mass. As a part of the management, he underwent a cervical lymph node biopsy, which showed metastatic deposits from papillary carcinoma thyroid. Subsequently, he underwent orchidectomy for...

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Autores principales: Bala, Ponnuthurai, Arjun, Padmanabhan, Varghese, Liju, Sudin, SR, Pillai, Sandeep, Thampy, Cherian, Palangadan, Shaji, Biji, KA
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7857364/
https://www.ncbi.nlm.nih.gov/pubmed/32883906
http://dx.doi.org/10.4103/lungindia.lungindia_378_19
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author Bala, Ponnuthurai
Arjun, Padmanabhan
Varghese, Liju
Sudin, SR
Pillai, Sandeep
Thampy, Cherian
Palangadan, Shaji
Biji, KA
author_facet Bala, Ponnuthurai
Arjun, Padmanabhan
Varghese, Liju
Sudin, SR
Pillai, Sandeep
Thampy, Cherian
Palangadan, Shaji
Biji, KA
author_sort Bala, Ponnuthurai
collection PubMed
description A 49-year-old male was evaluated in our hospital for chronic cough, cervical lymphadenopathy, and a testicular mass. As a part of the management, he underwent a cervical lymph node biopsy, which showed metastatic deposits from papillary carcinoma thyroid. Subsequently, he underwent orchidectomy for suspected testicular malignancy, but the biopsy showed discrete granulomatous inflammation consistent with sarcoidosis. This was followed by total thyroidectomy with neck node dissection. Nodal histopathological examination, this time, revealed a single node containing both malignancy and granulomas. Prior to the thyroid surgery, he underwent a mediastinoscopic sampling of the mediastinal nodes, which also showed granulomatous inflammation consistent with sarcoidosis. Sarcoidosis affecting the genitourinary system is a rare entity. The coexistence of sarcoidosis and thyroid malignancy poses a diagnostic challenge. A thorough review of the literature was done, and there are no reports from India on the above association. This is a unique case, which could possibly suggest an association between sarcoidosis and malignancy and highlights the importance of obtaining a tissue diagnosis in such cases.
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spelling pubmed-78573642021-02-05 A red herring, a wild-goose chase, and an unexpected diagnosis of concomitant malignancy and sarcoidosis Bala, Ponnuthurai Arjun, Padmanabhan Varghese, Liju Sudin, SR Pillai, Sandeep Thampy, Cherian Palangadan, Shaji Biji, KA Lung India Case Report A 49-year-old male was evaluated in our hospital for chronic cough, cervical lymphadenopathy, and a testicular mass. As a part of the management, he underwent a cervical lymph node biopsy, which showed metastatic deposits from papillary carcinoma thyroid. Subsequently, he underwent orchidectomy for suspected testicular malignancy, but the biopsy showed discrete granulomatous inflammation consistent with sarcoidosis. This was followed by total thyroidectomy with neck node dissection. Nodal histopathological examination, this time, revealed a single node containing both malignancy and granulomas. Prior to the thyroid surgery, he underwent a mediastinoscopic sampling of the mediastinal nodes, which also showed granulomatous inflammation consistent with sarcoidosis. Sarcoidosis affecting the genitourinary system is a rare entity. The coexistence of sarcoidosis and thyroid malignancy poses a diagnostic challenge. A thorough review of the literature was done, and there are no reports from India on the above association. This is a unique case, which could possibly suggest an association between sarcoidosis and malignancy and highlights the importance of obtaining a tissue diagnosis in such cases. Wolters Kluwer - Medknow 2020 2020-08-31 /pmc/articles/PMC7857364/ /pubmed/32883906 http://dx.doi.org/10.4103/lungindia.lungindia_378_19 Text en Copyright: © 2020 Indian Chest Society http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Case Report
Bala, Ponnuthurai
Arjun, Padmanabhan
Varghese, Liju
Sudin, SR
Pillai, Sandeep
Thampy, Cherian
Palangadan, Shaji
Biji, KA
A red herring, a wild-goose chase, and an unexpected diagnosis of concomitant malignancy and sarcoidosis
title A red herring, a wild-goose chase, and an unexpected diagnosis of concomitant malignancy and sarcoidosis
title_full A red herring, a wild-goose chase, and an unexpected diagnosis of concomitant malignancy and sarcoidosis
title_fullStr A red herring, a wild-goose chase, and an unexpected diagnosis of concomitant malignancy and sarcoidosis
title_full_unstemmed A red herring, a wild-goose chase, and an unexpected diagnosis of concomitant malignancy and sarcoidosis
title_short A red herring, a wild-goose chase, and an unexpected diagnosis of concomitant malignancy and sarcoidosis
title_sort red herring, a wild-goose chase, and an unexpected diagnosis of concomitant malignancy and sarcoidosis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7857364/
https://www.ncbi.nlm.nih.gov/pubmed/32883906
http://dx.doi.org/10.4103/lungindia.lungindia_378_19
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