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Autoantibodies against type I IFNs in patients with life-threatening COVID-19
Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for the Advancement of Science
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7857397/ https://www.ncbi.nlm.nih.gov/pubmed/32972996 http://dx.doi.org/10.1126/science.abd4585 |
| _version_ | 1783646439419674624 |
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| author | Bastard, Paul Rosen, Lindsey B. Zhang, Qian Michailidis, Eleftherios Hoffmann, Hans-Heinrich Zhang, Yu Dorgham, Karim Philippot, Quentin Rosain, Jérémie Béziat, Vivien Manry, Jérémy Shaw, Elana Haljasmägi, Liis Peterson, Pärt Lorenzo, Lazaro Bizien, Lucy Trouillet-Assant, Sophie Dobbs, Kerry de Jesus, Adriana Almeida Belot, Alexandre Kallaste, Anne Catherinot, Emilie Tandjaoui-Lambiotte, Yacine Le Pen, Jeremie Kerner, Gaspard Bigio, Benedetta Seeleuthner, Yoann Yang, Rui Bolze, Alexandre Spaan, András N. Delmonte, Ottavia M. Abers, Michael S. Aiuti, Alessandro Casari, Giorgio Lampasona, Vito Piemonti, Lorenzo Ciceri, Fabio Bilguvar, Kaya Lifton, Richard P. Vasse, Marc Smadja, David M. Migaud, Mélanie Hadjadj, Jérome Terrier, Benjamin Duffy, Darragh Quintana-Murci, Lluis van de Beek, Diederik Roussel, Lucie Vinh, Donald C. Tangye, Stuart G. Haerynck, Filomeen Dalmau, David Martinez-Picado, Javier Brodin, Petter Nussenzweig, Michel C. Boisson-Dupuis, Stéphanie Rodríguez-Gallego, Carlos Vogt, Guillaume Mogensen, Trine H. Oler, Andrew J. Gu, Jingwen Burbelo, Peter D. Cohen, Jeffrey I. Biondi, Andrea Bettini, Laura Rachele D'Angio, Mariella Bonfanti, Paolo Rossignol, Patrick Mayaux, Julien Rieux-Laucat, Frédéric Husebye, Eystein S. Fusco, Francesca Ursini, Matilde Valeria Imberti, Luisa Sottini, Alessandra Paghera, Simone Quiros-Roldan, Eugenia Rossi, Camillo Castagnoli, Riccardo Montagna, Daniela Licari, Amelia Marseglia, Gian Luigi Duval, Xavier Ghosn, Jade Tsang, John S. Goldbach-Mansky, Raphaela Kisand, Kai Lionakis, Michail S. Puel, Anne Zhang, Shen-Ying Holland, Steven M. Gorochov, Guy Jouanguy, Emmanuelle Rice, Charles M. Cobat, Aurélie Notarangelo, Luigi D. Abel, Laurent Su, Helen C. Casanova, Jean-Laurent |
| author_facet | Bastard, Paul Rosen, Lindsey B. Zhang, Qian Michailidis, Eleftherios Hoffmann, Hans-Heinrich Zhang, Yu Dorgham, Karim Philippot, Quentin Rosain, Jérémie Béziat, Vivien Manry, Jérémy Shaw, Elana Haljasmägi, Liis Peterson, Pärt Lorenzo, Lazaro Bizien, Lucy Trouillet-Assant, Sophie Dobbs, Kerry de Jesus, Adriana Almeida Belot, Alexandre Kallaste, Anne Catherinot, Emilie Tandjaoui-Lambiotte, Yacine Le Pen, Jeremie Kerner, Gaspard Bigio, Benedetta Seeleuthner, Yoann Yang, Rui Bolze, Alexandre Spaan, András N. Delmonte, Ottavia M. Abers, Michael S. Aiuti, Alessandro Casari, Giorgio Lampasona, Vito Piemonti, Lorenzo Ciceri, Fabio Bilguvar, Kaya Lifton, Richard P. Vasse, Marc Smadja, David M. Migaud, Mélanie Hadjadj, Jérome Terrier, Benjamin Duffy, Darragh Quintana-Murci, Lluis van de Beek, Diederik Roussel, Lucie Vinh, Donald C. Tangye, Stuart G. Haerynck, Filomeen Dalmau, David Martinez-Picado, Javier Brodin, Petter Nussenzweig, Michel C. Boisson-Dupuis, Stéphanie Rodríguez-Gallego, Carlos Vogt, Guillaume Mogensen, Trine H. Oler, Andrew J. Gu, Jingwen Burbelo, Peter D. Cohen, Jeffrey I. Biondi, Andrea Bettini, Laura Rachele D'Angio, Mariella Bonfanti, Paolo Rossignol, Patrick Mayaux, Julien Rieux-Laucat, Frédéric Husebye, Eystein S. Fusco, Francesca Ursini, Matilde Valeria Imberti, Luisa Sottini, Alessandra Paghera, Simone Quiros-Roldan, Eugenia Rossi, Camillo Castagnoli, Riccardo Montagna, Daniela Licari, Amelia Marseglia, Gian Luigi Duval, Xavier Ghosn, Jade Tsang, John S. Goldbach-Mansky, Raphaela Kisand, Kai Lionakis, Michail S. Puel, Anne Zhang, Shen-Ying Holland, Steven M. Gorochov, Guy Jouanguy, Emmanuelle Rice, Charles M. Cobat, Aurélie Notarangelo, Luigi D. Abel, Laurent Su, Helen C. Casanova, Jean-Laurent |
| author_sort | Bastard, Paul |
| collection | PubMed |
| description | Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-ω (IFN-ω) (13 patients), against the 13 types of IFN-α (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 of the 101 were men. A B cell autoimmune phenocopy of inborn errors of type I IFN immunity accounts for life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men. |
| format | Online Article Text |
| id | pubmed-7857397 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | American Association for the Advancement of Science |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-78573972021-02-05 Autoantibodies against type I IFNs in patients with life-threatening COVID-19 Bastard, Paul Rosen, Lindsey B. Zhang, Qian Michailidis, Eleftherios Hoffmann, Hans-Heinrich Zhang, Yu Dorgham, Karim Philippot, Quentin Rosain, Jérémie Béziat, Vivien Manry, Jérémy Shaw, Elana Haljasmägi, Liis Peterson, Pärt Lorenzo, Lazaro Bizien, Lucy Trouillet-Assant, Sophie Dobbs, Kerry de Jesus, Adriana Almeida Belot, Alexandre Kallaste, Anne Catherinot, Emilie Tandjaoui-Lambiotte, Yacine Le Pen, Jeremie Kerner, Gaspard Bigio, Benedetta Seeleuthner, Yoann Yang, Rui Bolze, Alexandre Spaan, András N. Delmonte, Ottavia M. Abers, Michael S. Aiuti, Alessandro Casari, Giorgio Lampasona, Vito Piemonti, Lorenzo Ciceri, Fabio Bilguvar, Kaya Lifton, Richard P. Vasse, Marc Smadja, David M. Migaud, Mélanie Hadjadj, Jérome Terrier, Benjamin Duffy, Darragh Quintana-Murci, Lluis van de Beek, Diederik Roussel, Lucie Vinh, Donald C. Tangye, Stuart G. Haerynck, Filomeen Dalmau, David Martinez-Picado, Javier Brodin, Petter Nussenzweig, Michel C. Boisson-Dupuis, Stéphanie Rodríguez-Gallego, Carlos Vogt, Guillaume Mogensen, Trine H. Oler, Andrew J. Gu, Jingwen Burbelo, Peter D. Cohen, Jeffrey I. Biondi, Andrea Bettini, Laura Rachele D'Angio, Mariella Bonfanti, Paolo Rossignol, Patrick Mayaux, Julien Rieux-Laucat, Frédéric Husebye, Eystein S. Fusco, Francesca Ursini, Matilde Valeria Imberti, Luisa Sottini, Alessandra Paghera, Simone Quiros-Roldan, Eugenia Rossi, Camillo Castagnoli, Riccardo Montagna, Daniela Licari, Amelia Marseglia, Gian Luigi Duval, Xavier Ghosn, Jade Tsang, John S. Goldbach-Mansky, Raphaela Kisand, Kai Lionakis, Michail S. Puel, Anne Zhang, Shen-Ying Holland, Steven M. Gorochov, Guy Jouanguy, Emmanuelle Rice, Charles M. Cobat, Aurélie Notarangelo, Luigi D. Abel, Laurent Su, Helen C. Casanova, Jean-Laurent Science Research Articles Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-ω (IFN-ω) (13 patients), against the 13 types of IFN-α (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 of the 101 were men. A B cell autoimmune phenocopy of inborn errors of type I IFN immunity accounts for life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men. American Association for the Advancement of Science 2020-10-23 2020-09-24 /pmc/articles/PMC7857397/ /pubmed/32972996 http://dx.doi.org/10.1126/science.abd4585 Text en Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works https://creativecommons.org/licenses/by/4.0/ https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution license (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Research Articles Bastard, Paul Rosen, Lindsey B. Zhang, Qian Michailidis, Eleftherios Hoffmann, Hans-Heinrich Zhang, Yu Dorgham, Karim Philippot, Quentin Rosain, Jérémie Béziat, Vivien Manry, Jérémy Shaw, Elana Haljasmägi, Liis Peterson, Pärt Lorenzo, Lazaro Bizien, Lucy Trouillet-Assant, Sophie Dobbs, Kerry de Jesus, Adriana Almeida Belot, Alexandre Kallaste, Anne Catherinot, Emilie Tandjaoui-Lambiotte, Yacine Le Pen, Jeremie Kerner, Gaspard Bigio, Benedetta Seeleuthner, Yoann Yang, Rui Bolze, Alexandre Spaan, András N. Delmonte, Ottavia M. Abers, Michael S. Aiuti, Alessandro Casari, Giorgio Lampasona, Vito Piemonti, Lorenzo Ciceri, Fabio Bilguvar, Kaya Lifton, Richard P. Vasse, Marc Smadja, David M. Migaud, Mélanie Hadjadj, Jérome Terrier, Benjamin Duffy, Darragh Quintana-Murci, Lluis van de Beek, Diederik Roussel, Lucie Vinh, Donald C. Tangye, Stuart G. Haerynck, Filomeen Dalmau, David Martinez-Picado, Javier Brodin, Petter Nussenzweig, Michel C. Boisson-Dupuis, Stéphanie Rodríguez-Gallego, Carlos Vogt, Guillaume Mogensen, Trine H. Oler, Andrew J. Gu, Jingwen Burbelo, Peter D. Cohen, Jeffrey I. Biondi, Andrea Bettini, Laura Rachele D'Angio, Mariella Bonfanti, Paolo Rossignol, Patrick Mayaux, Julien Rieux-Laucat, Frédéric Husebye, Eystein S. Fusco, Francesca Ursini, Matilde Valeria Imberti, Luisa Sottini, Alessandra Paghera, Simone Quiros-Roldan, Eugenia Rossi, Camillo Castagnoli, Riccardo Montagna, Daniela Licari, Amelia Marseglia, Gian Luigi Duval, Xavier Ghosn, Jade Tsang, John S. Goldbach-Mansky, Raphaela Kisand, Kai Lionakis, Michail S. Puel, Anne Zhang, Shen-Ying Holland, Steven M. Gorochov, Guy Jouanguy, Emmanuelle Rice, Charles M. Cobat, Aurélie Notarangelo, Luigi D. Abel, Laurent Su, Helen C. Casanova, Jean-Laurent Autoantibodies against type I IFNs in patients with life-threatening COVID-19 |
| title | Autoantibodies against type I IFNs in patients with life-threatening COVID-19 |
| title_full | Autoantibodies against type I IFNs in patients with life-threatening COVID-19 |
| title_fullStr | Autoantibodies against type I IFNs in patients with life-threatening COVID-19 |
| title_full_unstemmed | Autoantibodies against type I IFNs in patients with life-threatening COVID-19 |
| title_short | Autoantibodies against type I IFNs in patients with life-threatening COVID-19 |
| title_sort | autoantibodies against type i ifns in patients with life-threatening covid-19 |
| topic | Research Articles |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7857397/ https://www.ncbi.nlm.nih.gov/pubmed/32972996 http://dx.doi.org/10.1126/science.abd4585 |
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